| Literature DB >> 11871905 |
Eduardo Peña-Cabrera1, Lanny S Liebeskind.
Abstract
The total synthesis of echinochrome A is described. Both key intermediates 5 and 8 were efficiently prepared from diisopropyl squarate 7. Nucleophilic addition of aryllithium 8 to 5, followed by thermal ring-expansion/cyclization of the 1,2-adduct 4, furnished hydroquinone 3. Oxidation and full deprotection of 3 gave the title compound.Entities:
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Year: 2002 PMID： 11871905 DOI： 10.1021/jo016034m
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354