| Literature DB >> 11871887 |
Masahiko Isaka1, Chotika Suyarnsestakorn, Morakot Tanticharoen, Palangpon Kongsaeree, Yodhathai Thebtaranonth.
Abstract
Aigialomycins A-E (2-6), new 14-membered resorcylic macrolides, were isolated together with a known hypothemycin (1) from the mangrove fungus, Aigialus parvus BCC 5311. Structures of these compounds, including absolute configuration, were elucidated by spectroscopic methods, chemical conversions, and X-ray crystallographic analysis. Hypothemycin and aigialomycin D (5) exhibited in vitro antimalarial activity with IC(50) values of 2.2 and 6.6 microg/mL, respectively, while other analogues were inactive. Cytotoxicities of these compounds were also evaluated.Entities:
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Year: 2002 PMID： 11871887 DOI： 10.1021/jo010930g
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354