OBJECTIVES: This study investigated the impact of physical workload on the risk of severe knee osteoarthritis (OA) leading to knee arthroplasty. METHODS: In this case-referent study, the cases were 55- to 75-year-old men (N=55) and women (N=226) who had undergone their first knee arthroplasty operation for primary knee OA in the Kuopio University Hospital in 1992-1993. The referents (N=524) were from the same source population and were matched with the cases for age and gender. Information on explanatory variables was obtained by a computer-assisted telephone interview. Exposure was assessed up to 49 years of age. RESULTS: After adjustment for body mass index, knee injury and leisure-time physical activity, an increased relative risk of knee OA was found for a history of high physical workload. The odds ratio (OR) was 1.53 [95% confidence interval (95% CI) 0.42-5.56] for the men and 2.03 (95% CI 1.03-3.99) for the women as compared with those with low physical workload. With respect to generic risk factors, climbing already at a medium level of exposure was associated with an increased risk of knee OA among the men (OR 3.06, 95% CI 1.25-7.46) and kneeling and squatting was a risk factor for both genders. Of the different trades, agriculture, forestry, fishing, transportation, and traffic showed the highest risks of knee OA. CONCLUSIONS: The results of this study agree with the hypotheses that heavy physical loading increases the risk of knee OA and that cumulative physical stress has a deleterious effect on the knee joint.
OBJECTIVES: This study investigated the impact of physical workload on the risk of severe knee osteoarthritis (OA) leading to knee arthroplasty. METHODS: In this case-referent study, the cases were 55- to 75-year-old men (N=55) and women (N=226) who had undergone their first knee arthroplasty operation for primary knee OA in the Kuopio University Hospital in 1992-1993. The referents (N=524) were from the same source population and were matched with the cases for age and gender. Information on explanatory variables was obtained by a computer-assisted telephone interview. Exposure was assessed up to 49 years of age. RESULTS: After adjustment for body mass index, knee injury and leisure-time physical activity, an increased relative risk of knee OA was found for a history of high physical workload. The odds ratio (OR) was 1.53 [95% confidence interval (95% CI) 0.42-5.56] for the men and 2.03 (95% CI 1.03-3.99) for the women as compared with those with low physical workload. With respect to generic risk factors, climbing already at a medium level of exposure was associated with an increased risk of knee OA among the men (OR 3.06, 95% CI 1.25-7.46) and kneeling and squatting was a risk factor for both genders. Of the different trades, agriculture, forestry, fishing, transportation, and traffic showed the highest risks of knee OA. CONCLUSIONS: The results of this study agree with the hypotheses that heavy physical loading increases the risk of knee OA and that cumulative physical stress has a deleterious effect on the knee joint.
Authors: Prem Ramakrishnan; Benjamin A Hecht; Douglas R Pedersen; Matthew R Lavery; Jerry Maynard; Joseph A Buckwalter; James A Martin Journal: J Orthop Res Date: 2010-07 Impact factor: 3.494
Authors: Leigh F Callahan; Jack Shreffler; Bernadette C Siaton; Charles G Helmick; Britta Schoster; Todd A Schwartz; Jiu-Chiuan Chen; Jordan B Renner; Joanne M Jordan Journal: Arthritis Res Ther Date: 2010-03-18 Impact factor: 5.156
Authors: M Rossignol; A Leclerc; P Hilliquin; F A Allaert; S Rozenberg; J-P Valat; B Avouac; P Coste; B Savarieau; B Fautrel Journal: Occup Environ Med Date: 2003-11 Impact factor: 4.402
Authors: Niklas Krause; Richard J Brand; Jussi Kauhanen; George A Kaplan; S Leonard Syme; Candice C Wong; Jukka T Salonen Journal: Prev Chronic Dis Date: 2008-12-15 Impact factor: 2.830