OBJECTIVES: We sought to investigate the role of cardiotropic viruses, including adenovirus, cytomegalovirus (CMV), enterovirus and parvovirus, in arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). BACKGROUND: Arrhythmogenic right ventricular dysplasia/cardiomyopathy is characterized by a gradual loss of myocytes, inflammatory infiltrates and replacement by fatty and fibrous tissue. It has been speculated that ARVD/C is a sequela of viral myocarditis in some patients, and the role of the coxsackievirus B3 has been debated. METHODS: Myocardial samples from 12 patients with ARVD/C were analyzed by polymerase chain reaction for the presence of cardiotropic viruses. RESULTS: Enteroviral sequences were detected in seven patients and adenovirus type 5 in another two patients. During the same period, 215 control samples were analyzed in which only CMV (n = 2) and enterovirus (n = 1) were detected. This suggests a link between ARVD/C and the presence of viral genome (enterovirus or adenovirus) in the myocardium. CONCLUSIONS: We report that cardiotropic viruses are more frequently identified in patients with ARVD/C than in control subjects. However, the role of these viruses in ARVD/C pathogenesis remains unknown.
OBJECTIVES: We sought to investigate the role of cardiotropic viruses, including adenovirus, cytomegalovirus (CMV), enterovirus and parvovirus, in arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). BACKGROUND:Arrhythmogenic right ventricular dysplasia/cardiomyopathy is characterized by a gradual loss of myocytes, inflammatory infiltrates and replacement by fatty and fibrous tissue. It has been speculated that ARVD/C is a sequela of viral myocarditis in some patients, and the role of the coxsackievirus B3 has been debated. METHODS: Myocardial samples from 12 patients with ARVD/C were analyzed by polymerase chain reaction for the presence of cardiotropic viruses. RESULTS: Enteroviral sequences were detected in seven patients and adenovirus type 5 in another two patients. During the same period, 215 control samples were analyzed in which only CMV (n = 2) and enterovirus (n = 1) were detected. This suggests a link between ARVD/C and the presence of viral genome (enterovirus or adenovirus) in the myocardium. CONCLUSIONS: We report that cardiotropic viruses are more frequently identified in patients with ARVD/C than in control subjects. However, the role of these viruses in ARVD/C pathogenesis remains unknown.
Authors: Guoliang Li; Guy H Fontaine; Shuanliang Fan; Yang Yan; Peter K Bode; Firat Duru; Robert Frank; Ardan M Saguner Journal: Cardiol J Date: 2018-11-05 Impact factor: 2.737
Authors: Frank I Marcus; Wojciech Zareba; Hugh Calkins; Jeffrey A Towbin; Cristina Basso; David A Bluemke; N A Mark Estes; Michael H Picard; Danita Sanborn; Gaetano Thiene; Thomas Wichter; David Cannom; David J Wilber; Melvin Scheinman; Henry Duff; James Daubert; Mario Talajic; Andrew Krahn; Michael Sweeney; Hasan Garan; Scott Sakaguchi; Bruce B Lerman; Charles Kerr; Jack Kron; Jonathan S Steinberg; Duane Sherrill; Kathleen Gear; Mary Brown; Patricia Severski; Slava Polonsky; Scott McNitt Journal: Heart Rhythm Date: 2009-03-11 Impact factor: 6.343