Pierre M Gholam1, Donald P Kotler, Louis J Flancbaum. 1. Department of Medicine, Theodore Van Itallie Obesity Research and Treatment Center, St Luke's-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY, USA. NYCGIDOC@aol.com
Abstract
BACKGROUND: Non-alcoholic fatty liver disease is common. However, little is known about liver disease in the morbidly obese. METHODS: 75 subjects (78% female, mean BMI 57 [40-108]) who had intra-operative liver biopsies at the time of Roux-en-Y gastric bypass surgery were studied. RESULTS: 84% of subjects had steatosis while only about 20% had moderate to severe inflammation and fibrosis. 8% had bridging fibrosis or cirrhosis. The presence of fibrosis correlated strongly with the presence of inflammation (p < 0.001) and steatosis (p = 0.0011), but weakly with ALT (p = 0.02) and not with AST (p = 0.12) or with BMI (p = 0.34). Steatosis correlated with AST (p = 0.04) and ALT (p = 0.055), but not with BMI. CONCLUSION: Liver disease is not rare in the morbidly obese. The exact causes and mechanisms that lead from the very common isolated steatosis to inflammation and fibrosis remain unclear. Intra-operative liver biopsies during bariatric surgery may be helpful to screen for the presence of steatohepatitis and fibrosis.
BACKGROUND:Non-alcoholic fatty liver disease is common. However, little is known about liver disease in the morbidly obese. METHODS: 75 subjects (78% female, mean BMI 57 [40-108]) who had intra-operative liver biopsies at the time of Roux-en-Y gastric bypass surgery were studied. RESULTS: 84% of subjects had steatosis while only about 20% had moderate to severe inflammation and fibrosis. 8% had bridging fibrosis or cirrhosis. The presence of fibrosis correlated strongly with the presence of inflammation (p < 0.001) and steatosis (p = 0.0011), but weakly with ALT (p = 0.02) and not with AST (p = 0.12) or with BMI (p = 0.34). Steatosis correlated with AST (p = 0.04) and ALT (p = 0.055), but not with BMI. CONCLUSION:Liver disease is not rare in the morbidly obese. The exact causes and mechanisms that lead from the very common isolated steatosis to inflammation and fibrosis remain unclear. Intra-operative liver biopsies during bariatric surgery may be helpful to screen for the presence of steatohepatitis and fibrosis.