Literature DB >> 11867095

Cytotoxic withanolides from Acnistus arborescens.

Sandro Minguzzi1, Lauro E S Barata, Young Geun Shin, Patrick F Jonas, Hee Byung Chai, Eun Jung Park, John M Pezzuto, Geoffrey A Cordell.   

Abstract

Three cytotoxic withanolides, two with new structures, were isolated from the leaves of Acnistus arborescens and their structures determined by a combination of 1D and 2D NMR, mass spectral, and molecular modeling studies. Dereplication analysis of the ethyl ether extract was useful for evaluating the components showing significant cytotoxic activity.

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Year:  2002        PMID: 11867095     DOI: 10.1016/s0031-9422(02)00022-5

Source DB:  PubMed          Journal:  Phytochemistry        ISSN: 0031-9422            Impact factor:   4.072


  7 in total

1.  Dinoxin B, a withanolide from Datura inoxia leaves with specific cytotoxic activities.

Authors:  Karl Vermillion; F Omar Holguin; Mark A Berhow; Richard D Richins; Thurman Redhouse; Mary A O'Connell; Jeff Posakony; Sumit S Mahajan; Sean M Kelly; Julian A Simon
Journal:  J Nat Prod       Date:  2011-01-31       Impact factor: 4.050

2.  Withasteroid B from D. metel L. regulates immune responses by modulating the JAK/STAT pathway and the IL-17+ RORγt+ /IL-10+ FoxP3+ ratio.

Authors:  Y Su; Q Wang; B Yang; L Wu; G Cheng; H Kuang
Journal:  Clin Exp Immunol       Date:  2017-08-04       Impact factor: 4.330

3.  Cell cycle arrest through inhibition of tubulin polymerization by withaphysalin F, a bioactive compound isolated from Acnistus arborescens.

Authors:  Danilo D Rocha; Aruna Balgi; Ana Isabel V Maia; Otilia D Pessoa; Edilberto R Silveira; Letícia V Costa-Lotufo; Michel Roberge; Claudia Pessoa
Journal:  Invest New Drugs       Date:  2011-03-18       Impact factor: 3.850

4.  Minor withanolides of Physalis longifolia: structure and cytotoxicity.

Authors:  Huaping Zhang; Hashim Motiwala; Abbas Samadi; Victor Day; Jeffrey Aubé; Mark Cohen; Kelly Kindscher; Rao Gollapudi; Barbara Timmermann
Journal:  Chem Pharm Bull (Tokyo)       Date:  2012       Impact factor: 1.645

5.  Anti-proliferative withanolides from the Solanaceae: a structure-activity study.

Authors:  Huaping Zhang; Abbas K Samadi; Mark S Cohen; Barbara N Timmermann
Journal:  Pure Appl Chem       Date:  2012       Impact factor: 2.453

Review 6.  Natural Withanolides in the Treatment of Chronic Diseases.

Authors:  Peter T White; Chitra Subramanian; Hashim F Motiwala; Mark S Cohen
Journal:  Adv Exp Med Biol       Date:  2016       Impact factor: 2.622

7.  Structural Characterization of Withanolide Glycosides from the Roots of Withania somnifera and Their Potential Biological Activities.

Authors:  Ji Won Ha; Jae Sik Yu; Bum Soo Lee; Dong-Min Kang; Mi-Jeong Ahn; Jung Kyu Kim; Ki Hyun Kim
Journal:  Plants (Basel)       Date:  2022-03-13
  7 in total

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