Literature DB >> 11866590

The synthesis and biological characterization of a ceramide library.

Young-Tae Chang1, Jaehwa Choi, Sheng Ding, Eva E Prieschl, Thomas Baumruker, Jae-Mok Lee, Sung-Kee Chung, Peter G Schultz.   

Abstract

A facile synthesis of a combinatorial ceramide library and their activities in the NF-kappaB pathway and in apoptosis induction/prevention were demonstrated. A novel NF-kappaB activating molecule was discovered among ceramide containing beta-galactose, and the structural requirements of ceramides for apoptosis induction was elucidated.

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Year:  2002        PMID： 11866590     DOI： 10.1021/ja017576o

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  9 in total

1.  Synthesis of all stereoisomers of KRN7000, the CD1d-binding NKT cell ligand.

Authors:  Jeong-Ju Park; Ji Hyung Lee; Subhash C Ghosh; Gabriel Bricard; Manjunatha M Venkataswamy; Steven A Porcelli; Sung-Kee Chung
Journal:  Bioorg Med Chem Lett       Date:  2008-06-14       Impact factor: 2.823

Review 2.  Amide Bond Bioisosteres: Strategies, Synthesis, and Successes.

Authors:  Shikha Kumari; Angelica V Carmona; Amit K Tiwari; Paul C Trippier
Journal:  J Med Chem       Date:  2020-08-04       Impact factor: 7.446

3.  Cytotoxic Activity and Structure Activity Relationship of Ceramide Analogues in Caki-2 and HL-60 Cells.

Authors:  Yong Jin Kim; Eun Ae Kim; Uy Dong Sohn; Chul Bu Yim; Chaeuk Im
Journal:  Korean J Physiol Pharmacol       Date:  2010-12-31       Impact factor: 2.016

4.  Ceramides: branched alkyl chains in the sphingolipid siblings of diacylglycerol improve biological potency.

Authors:  Ji-Hye Kang; Himanshu Garg; Dina M Sigano; Nicholas Francella; Robert Blumenthal; Victor E Marquez
Journal:  Bioorg Med Chem       Date:  2009-01-11       Impact factor: 3.641

Review 5.  The adipokine/ceramide axis: key aspects of insulin sensitization.

Authors:  Jonathan Y Xia; Thomas S Morley; Philipp E Scherer
Journal:  Biochimie       Date:  2013-08-20       Impact factor: 4.079

6.  Syntheses and biological activities of KRN7000 analogues having aromatic residues in the acyl and backbone chains with varying stereochemistry.

Authors:  Jeong-Ju Park; Ji Hyung Lee; Kyung-Chang Seo; Gabriel Bricard; Manjunatha M Venkataswamy; Steven A Porcelli; Sung-Kee Chung
Journal:  Bioorg Med Chem Lett       Date:  2010-01-04       Impact factor: 2.823

7.  Cytotoxicities and Quantitative Structure Activity Relationships of B13 Sulfonamides in HT-29 and A549 Cells.

Authors:  Seul Ki Chan Lee; Sang Min Park; Chaeuk Im
Journal:  Korean J Physiol Pharmacol       Date:  2011-12-27       Impact factor: 2.016

8.  Facile Chemoselective Strategy toward Capturing Sphingoid Bases by a Unique Glutaraldehyde-Functionalized Resin.

Authors:  Siddabasave Gowda B Gowda; Atsufumi Nakahashi; Keiko Yamane; Saori Nakahashi; Yuta Murai; Ananda Kumar C Siddegowda; Mostafa A S Hammam; Kenji Monde
Journal:  ACS Omega       Date:  2018-01-22

9.  Palyosulfonoceramides A and B: unique sulfonylated ceramides from the Brazilian zoanthids Palythoa caribaeorum and Protopalythoa variabilis.

Authors:  Jose Gustavo L Almeida; Ana Isabel V Maia; Diego V Wilke; Edilberto R Silveira; Raimundo Braz-Filho; James J La Clair; Leticia V Costa-Lotufo; Otília Deusdenia L Pessoa
Journal:  Mar Drugs       Date:  2012-12-14       Impact factor: 5.118
  9 in total

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