OBJECTIVE: To examine the frequency of community-acquired salmonella bloodstream infection in Ghanaian children and the occurrence of antibiotic resistance in salmonellae. METHODS: The study comprised 472 patients with a blood culture obtained within 48 h of admission to the pediatric department of Korle Bu Teaching Hospital in Accra, Ghana, over a 3-month period. All Salmonella isolates from blood cultures were speciated and antibiotic susceptibility tests were performed. Clinical data of children with salmonella bloodstream infection were compared to those of controls. Two control groups were identified: all children enrolled in the study without salmonella bloodstream infection (group 1), and those with bloodstream infection due to other organisms (group 2). RESULTS: A pathogen was isolated from 111 children (23.5%), and salmonellae were among the most common isolates (n=24; 21.6%). Among Salmonella strains, S. enteritidis (n=14; 59%) predominated over S. typhi (n=6; 25%). Resistance to several antibiotics was only found in S. enteritidis isolates (n=8; 57%). Children with salmonella bloodstream infection presented more often than controls with severe anemia, jaundice, abdominal pain and distension as well as hepatomegaly and splenomegaly. They were also hospitalized for a significantly longer period, but the case-fatality rate was similar. CONCLUSIONS: Salmonella bloodstream infection, especially due to non-typhoidal strains, is a potential health problem for Ghanaian children and may be complicated by resistance to the commonly available antibiotics.
OBJECTIVE: To examine the frequency of community-acquired salmonella bloodstream infection in Ghanaian children and the occurrence of antibiotic resistance in salmonellae. METHODS: The study comprised 472 patients with a blood culture obtained within 48 h of admission to the pediatric department of Korle Bu Teaching Hospital in Accra, Ghana, over a 3-month period. All Salmonella isolates from blood cultures were speciated and antibiotic susceptibility tests were performed. Clinical data of children with salmonella bloodstream infection were compared to those of controls. Two control groups were identified: all children enrolled in the study without salmonella bloodstream infection (group 1), and those with bloodstream infection due to other organisms (group 2). RESULTS: A pathogen was isolated from 111 children (23.5%), and salmonellae were among the most common isolates (n=24; 21.6%). Among Salmonella strains, S. enteritidis (n=14; 59%) predominated over S. typhi (n=6; 25%). Resistance to several antibiotics was only found in S. enteritidis isolates (n=8; 57%). Children with salmonella bloodstream infection presented more often than controls with severe anemia, jaundice, abdominal pain and distension as well as hepatomegaly and splenomegaly. They were also hospitalized for a significantly longer period, but the case-fatality rate was similar. CONCLUSIONS:Salmonella bloodstream infection, especially due to non-typhoidal strains, is a potential health problem for Ghanaian children and may be complicated by resistance to the commonly available antibiotics.
Authors: Vera von Kalckreuth; Frank Konings; Peter Aaby; Yaw Adu-Sarkodie; Mohammad Ali; Abraham Aseffa; Stephen Baker; Robert F Breiman; Morten Bjerregaard-Andersen; John D Clemens; John A Crump; Ligia Maria Cruz Espinoza; Jessica Fung Deerin; Nagla Gasmelseed; Amy Gassama Sow; Justin Im; Karen H Keddy; Leonard Cosmas; Jürgen May; Christian G Meyer; Eric D Mintz; Joel M Montgomery; Beatrice Olack; Gi Deok Pak; Ursula Panzner; Se Eun Park; Raphaël Rakotozandrindrainy; Heidi Schütt-Gerowitt; Abdramane Bassiahi Soura; Michelle R Warren; Thomas F Wierzba; Florian Marks Journal: Clin Infect Dis Date: 2016-03-15 Impact factor: 9.079
Authors: Norbert G Schwarz; Nimako Sarpong; Frank Hünger; Florian Marks; Samuel Ek Acquah; Alex Agyekum; Bernard Nkrumah; Wibke Loag; Ralf M Hagen; Jennifer A Evans; Denise Dekker; Julius N Fobil; Christian G Meyer; Jürgen May; Yaw Adu-Sarkodie Journal: BMC Infect Dis Date: 2010-11-04 Impact factor: 3.090
Authors: Denise Myriam Dekker; Ralf Krumkamp; Nimako Sarpong; Hagen Frickmann; Kennedy Gyau Boahen; Michael Frimpong; Renate Asare; Richard Larbi; Ralf Matthias Hagen; Sven Poppert; Wolfgang Rabsch; Florian Marks; Yaw Adu-Sarkodie; Jürgen May Journal: Int J Environ Res Public Health Date: 2015-03-27 Impact factor: 3.390
Authors: Linda Aurelia Andoh; Shabana Ahmed; John Elmerdahl Olsen; Kwasi Obiri-Danso; Mercy Jemima Newman; Japheth Awuletey Opintan; Lisa Barco; Anders Dalsgaard Journal: Trop Med Health Date: 2017-02-10