PURPOSE: In this study, 16 paired samples of colorectal and gastric cancers and adjacent non-neoplastic tissues were analysed for the determination of glutathione S-transferase (GST) activities and the expression of GST-pi. METHODS: Western blotting procedure as well as plasma GST-pi levels were used. RESULTS: GST activities were found to be increased in malignant tissues of patient compared with adjacent normal tissues. A significant correlation was detected between GST activity and GST-pi expression in malignant tissues of patients. Plasma GST-pi levels increased in patients compared to aged-matched control subjects. When the patients were grouped according to TNM stage, GST-pi expression in malignant tissues as well as plasma GST-pi levels were higher in patients with more advanced tumor stages. CONCLUSIONS: Our results indicate that GST-pi expression in malignant tissues and plasma GST-pi levels in human colorectal and gastric cancers increased depending on the stages of tumor.
PURPOSE: In this study, 16 paired samples of colorectal and gastric cancers and adjacent non-neoplastic tissues were analysed for the determination of glutathione S-transferase (GST) activities and the expression of GST-pi. METHODS: Western blotting procedure as well as plasma GST-pi levels were used. RESULTS:GST activities were found to be increased in malignant tissues of patient compared with adjacent normal tissues. A significant correlation was detected between GST activity and GST-pi expression in malignant tissues of patients. Plasma GST-pi levels increased in patients compared to aged-matched control subjects. When the patients were grouped according to TNM stage, GST-pi expression in malignant tissues as well as plasma GST-pi levels were higher in patients with more advanced tumor stages. CONCLUSIONS: Our results indicate that GST-pi expression in malignant tissues and plasma GST-pi levels in humancolorectal and gastric cancers increased depending on the stages of tumor.
Authors: Milica Lj Stojkovic Lalosevic; Vesna M Coric; Tatjana D Pekmezovic; Tatjana P Simic; Marija S Pljesa Ercegovac; Aleksandra R Pavlovic Markovic; Zoran V Krivokapic Journal: Pathol Oncol Res Date: 2019-01-29 Impact factor: 3.201
Authors: Lucy Jankova; Graham Robertson; Charles Chan; King L Tan; Maija Kohonen-Corish; Caroline L-S Fung; Candice Clarke; Betty P C Lin; Mark Molloy; Pierre H Chapuis; Les Bokey; Owen F Dent; Stephen J Clarke Journal: BMC Cancer Date: 2012-05-28 Impact factor: 4.430