M Orsetti1, C Ferretti, RicciS Gamalero, P Ghi. 1. Dipartimento di Scienze C.A.F. e Farmacologiche, Università del Piemonte Orientale, Viale F. Ferrucci 33, 28100 Novara, Italy.
Abstract
RATIONALE: Several lines of evidence have indicated that the central histaminergic system might be involved in learning and memory OBJECTIVES: The aim of the present study was to ascertain the impact on memory processes of putative histaminergic-cholinergic interactions in the nucleus basalis magnocellularis (NBM) of the rat. METHODS: The effects of thioperamide, a histamine H3-receptor antagonist, were studied on the memory performance of rats in a two-trial, delayed, place-recognition task. The drug was injected into the NBM area 2 min prior to the first trial (1.5, 7.5, and 37.5 ng/0.5 microl; pre-acquisition treatment), within 30 s from the end of the first trial (0.3, 1.5, 7.5, and 37.5 ng/0.5 microl; post-acquisition treatment), or 2 min prior to the second trial (1.5, 7.5, and 37.5 ng/0.5 microl; pre-retrieval treatment). RESULTS: Post-acquisition intra-NBM injections of 1.5 ng and 7.5 ng, but not of 0.3 ng and 37.5 ng thioperamide, significantly enhanced memory retention in treated rats. The histamine H(3)-receptor blocker exerted pro-cognitive effects only when administered post-acquisition, since both pre-acquisition and pre-retrieval treatments were ineffective. The post-acquisition effect of the drug was time dependent and disappeared when the drug was injected 90 min after the end of the first trial. The U-shaped dose-response relationship and the time dependency of the effect of thioperamide indicated that the drug acts on mechanisms involved in memory consolidation. CONCLUSIONS: The present findings demonstrate that the pro-cognitive effect of thioperamide is probably due to the modulation of post-acquisition memory processes through an action on the cholinergic basal forebrain. Our results indicate also that H3-antagonists may provide a useful approach for improving spatial recognition memory.
RATIONALE: Several lines of evidence have indicated that the central histaminergic system might be involved in learning and memory OBJECTIVES: The aim of the present study was to ascertain the impact on memory processes of putative histaminergic-cholinergic interactions in the nucleus basalis magnocellularis (NBM) of the rat. METHODS: The effects of thioperamide, a histamine H3-receptor antagonist, were studied on the memory performance of rats in a two-trial, delayed, place-recognition task. The drug was injected into the NBM area 2 min prior to the first trial (1.5, 7.5, and 37.5 ng/0.5 microl; pre-acquisition treatment), within 30 s from the end of the first trial (0.3, 1.5, 7.5, and 37.5 ng/0.5 microl; post-acquisition treatment), or 2 min prior to the second trial (1.5, 7.5, and 37.5 ng/0.5 microl; pre-retrieval treatment). RESULTS: Post-acquisition intra-NBM injections of 1.5 ng and 7.5 ng, but not of 0.3 ng and 37.5 ng thioperamide, significantly enhanced memory retention in treated rats. The histamine H(3)-receptor blocker exerted pro-cognitive effects only when administered post-acquisition, since both pre-acquisition and pre-retrieval treatments were ineffective. The post-acquisition effect of the drug was time dependent and disappeared when the drug was injected 90 min after the end of the first trial. The U-shaped dose-response relationship and the time dependency of the effect of thioperamide indicated that the drug acts on mechanisms involved in memory consolidation. CONCLUSIONS: The present findings demonstrate that the pro-cognitive effect of thioperamide is probably due to the modulation of post-acquisition memory processes through an action on the cholinergic basal forebrain. Our results indicate also that H3-antagonists may provide a useful approach for improving spatial recognition memory.
Authors: Daniel D Savage; Martina J Rosenberg; Christina R Wolff; Katherine G Akers; Ahmed El-Emawy; Miranda C Staples; Rafael K Varaschin; Carrie A Wright; Jessica L Seidel; Kevin K Caldwell; Derek A Hamilton Journal: Alcohol Clin Exp Res Date: 2010-07-09 Impact factor: 3.455
Authors: David Moreno-Delgado; Mar Puigdellívol; Silvia Ginés; Peter J McCormick; Estefanía Moreno; Mar Rodríguez-Ruiz; Joaquín Botta; Paola Gasperini; Anna Chiarlone; Lesley A Howell; Marco Scarselli; Vicent Casadó; Antoni Cortés; Sergi Ferré; Manuel Guzmán; Carmen Lluís; Jordi Alberch; Enric I Canela Journal: Elife Date: 2020-06-09 Impact factor: 8.140