Literature DB >> 11861878

Efficient human immunodeficiency virus replication requires a fine-tuned level of transcription.

Giuseppe Marzio1, Monique Vink, Koen Verhoef, Anthony de Ronde, Ben Berkhout.   

Abstract

Transcription represents a crucial step in the life cycle of human immunodeficiency virus (HIV) and is highly regulated. Here we show that the strength of the viral long terminal repeat (LTR) promoter is optimized for efficient replication. Artificially increasing the rate of LTR-driven transcription was strongly detrimental for viral fitness, and HIV was able to regain replication capacity by selecting for variants with a weaker LTR. Strikingly, the strength of the evolved promoter was equivalent to that of the wild-type LTR.

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Year:  2002        PMID： 11861878      PMCID： PMC135974          DOI： 10.1128/jvi.76.6.3084-3088.2002

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  18 in total

Review 1.  Multifaceted activities of the HIV-1 transactivator of transcription, Tat.

Authors:  K T Jeang; H Xiao; E A Rich
Journal:  J Biol Chem       Date:  1999-10-08       Impact factor: 5.157

2.  DNA constraints on transcription activation in vitro.

Authors:  E D Ross; A M Keating
Journal:  J Mol Biol       Date:  2000-03-24       Impact factor: 5.469

3.  Replication of lengthened Moloney murine leukemia virus genomes is impaired at multiple stages.

Authors:  N H Shin; D Hartigan-O'Connor; J K Pfeiffer; A Telesnitsky
Journal:  J Virol       Date:  2000-03       Impact factor: 5.103

Review 4.  A compilation of cellular transcription factor interactions with the HIV-1 LTR promoter.

Authors:  L A Pereira; K Bentley; A Peeters; M J Churchill; N J Deacon
Journal:  Nucleic Acids Res       Date:  2000-02-01       Impact factor: 16.971

Review 5.  Cellular transcription factors involved in the regulation of HIV-1 gene expression.

Authors:  R Gaynor
Journal:  AIDS       Date:  1992-04       Impact factor: 4.177

6.  Tat trans-activates the human immunodeficiency virus through a nascent RNA target.

Authors:  B Berkhout; R H Silverman; K T Jeang
Journal:  Cell       Date:  1989-10-20       Impact factor: 41.582

7.  HIV-1 evolves into a nonsyncytium-inducing virus upon prolonged culture in vitro.

Authors:  A T Das; A Land; I Braakman; B Klaver; B Berkhout
Journal:  Virology       Date:  1999-10-10       Impact factor: 3.616

8.  The tetracycline-responsive promoter contains functional interferon-inducible response elements.

Authors:  A Rang; H Will
Journal:  Nucleic Acids Res       Date:  2000-03-01       Impact factor: 16.971

9.  Functional differences between the long terminal repeat transcriptional promoters of human immunodeficiency virus type 1 subtypes A through G.

Authors:  R E Jeeninga; M Hoogenkamp; M Armand-Ugon; M de Baar; K Verhoef; B Berkhout
Journal:  J Virol       Date:  2000-04       Impact factor: 5.103

10.  Genetic instability of live, attenuated human immunodeficiency virus type 1 vaccine strains.

Authors:  B Berkhout; K Verhoef; J L van Wamel; N K Back
Journal:  J Virol       Date:  1999-02       Impact factor: 5.103
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  17 in total

Review 1.  HIV-1 evolution: frustrating therapies, but disclosing molecular mechanisms.

Authors:  Atze T Das; Ben Berkhout
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2010-06-27       Impact factor: 6.237

2.  A doxycycline-dependent human immunodeficiency virus type 1 replicates in vivo without inducing CD4+ T-cell depletion.

Authors:  Nicolas Legrand; Gisela J van der Velden; Raphaël Ho Tsong Fang; Marc Douaisi; Kees Weijer; Atze T Das; Bianca Blom; Christel H Uittenbogaart; Ben Berkhout; Mireille Centlivre
Journal:  J Gen Virol       Date:  2012-05-30       Impact factor: 3.891

3.  Construction of a doxycycline-dependent simian immunodeficiency virus reveals a nontranscriptional function of tat in viral replication.

Authors:  Atze T Das; Bep Klaver; Alex Harwig; Monique Vink; Marcel Ooms; Mireille Centlivre; Ben Berkhout
Journal:  J Virol       Date:  2007-08-01       Impact factor: 5.103

4.  The HIV-1 Tat protein has a versatile role in activating viral transcription.

Authors:  Atze T Das; Alex Harwig; Ben Berkhout
Journal:  J Virol       Date:  2011-07-13       Impact factor: 5.103

5.  Caveolin-1 suppresses human immunodeficiency virus-1 replication by inhibiting acetylation of NF-κB.

Authors:  Glenn E Simmons; Harry E Taylor; James E K Hildreth
Journal:  Virology       Date:  2012-06-28       Impact factor: 3.616

6.  Possible applications for replicating HIV 1 vectors.

Authors:  Atze T Das; Rienk E Jeeninga; Ben Berkhout
Journal:  HIV Ther       Date:  2010-05-01

7.  Improving the safety of a conditional-live human immunodeficiency virus type 1 vaccine by controlling both gene expression and cell entry.

Authors:  Atze T Das; Chris E Baldwin; Monique Vink; Ben Berkhout
Journal:  J Virol       Date:  2005-03       Impact factor: 5.103

8.  The human immunodeficiency virus type 1 promoter contains a CATA box instead of a TATA box for optimal transcription and replication.

Authors:  Tim van Opijnen; Joost Kamoschinski; Rienk E Jeeninga; Ben Berkhout
Journal:  J Virol       Date:  2004-07       Impact factor: 5.103

9.  Theoretical design of a gene therapy to prevent AIDS but not human immunodeficiency virus type 1 infection.

Authors:  Leor S Weinberger; David V Schaffer; Adam P Arkin
Journal:  J Virol       Date:  2003-09       Impact factor: 5.103

10.  Replication of human immunodeficiency viruses engineered with heterologous Tat-transactivation response element interactions.

Authors:  Baode Xie; Mark A Wainberg; Alan D Frankel
Journal:  J Virol       Date:  2003-02       Impact factor: 5.103
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