Literature DB >> 11861872

CD28(-/-) mice show defects in cellular and humoral immunity but are able to control infection with murine gammaherpesvirus 68.

Bong Joo Lee1, Su Khoh Reiter, Mandy Anderson, Sally R Sarawar.   

Abstract

The role of CD28-dependent costimulatory interactions in the development and maintenance of antiviral immune responses was investigated in a mouse model of gammaherpesvirus infection. CD28(-/-) mice could clear a productive infection with murine gammaherpesvirus 68 (MHV-68), although early lung viral titers were significantly increased. Both CD28(-/-) and CD28(+/+) mice maintained effective long-term control of MHV-68. Gamma interferon responses appeared to develop more slowly in CD28(-/-) mice, while cytotoxic T-cell activity was similar to that in wild-type mice. Splenomegaly developed normally in CD28(-/-) mice, whereas virus-specific antibody responses were significantly reduced and aberrant class switching was observed. This work demonstrates that costimulatory interactions involving CD28 are not an absolute requirement for the control of infection with MHV-68.

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Year:  2002        PMID： 11861872      PMCID： PMC136005          DOI： 10.1128/jvi.76.6.3049-3053.2002

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  37 in total

Review 1.  CD28-B7 interactions in T-cell activation.

Authors:  J P Allison
Journal:  Curr Opin Immunol       Date:  1994-06       Impact factor: 7.486

2.  Antiviral immune responses in CTLA4 transgenic mice.

Authors:  C Zimmermann; P Seiler; P Lane; R M Zinkernagel
Journal:  J Virol       Date:  1997-03       Impact factor: 5.103

3.  Distinct costimulatory molecules are required for the induction of effector and memory cytotoxic T lymphocytes.

Authors:  Y Liu; R H Wenger; M Zhao; P J Nielsen
Journal:  J Exp Med       Date:  1997-01-20       Impact factor: 14.307

4.  Gamma interferon is not essential for recovery from acute infection with murine gammaherpesvirus 68.

Authors:  S R Sarawar; R D Cardin; J W Brooks; M Mehrpooya; A M Hamilton-Easton; X Y Mo; P C Doherty
Journal:  J Virol       Date:  1997-05       Impact factor: 5.103

5.  Duration of TCR stimulation determines costimulatory requirement of T cells.

Authors:  T M Kündig; A Shahinian; K Kawai; H W Mittrücker; E Sebzda; M F Bachmann; T W Mak; P S Ohashi
Journal:  Immunity       Date:  1996-07       Impact factor: 31.745

6.  Costimulation of CD28- T lymphocytes by 4-1BB ligand.

Authors:  M A DeBenedette; A Shahinian; T W Mak; T H Watts
Journal:  J Immunol       Date:  1997-01-15       Impact factor: 5.422

7.  Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells.

Authors:  R D Cardin; J W Brooks; S R Sarawar; P C Doherty
Journal:  J Exp Med       Date:  1996-09-01       Impact factor: 14.307

8.  Pathogenesis of murine gammaherpesvirus infection in mice deficient in CD4 and CD8 T cells.

Authors:  S Ehtisham; N P Sunil-Chandra; A A Nash
Journal:  J Virol       Date:  1993-09       Impact factor: 5.103

9.  Concurrent production of interleukin-2, interleukin-10, and gamma interferon in the regional lymph nodes of mice with influenza pneumonia.

Authors:  S R Sarawar; P C Doherty
Journal:  J Virol       Date:  1994-05       Impact factor: 5.103

10.  Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

Authors:  M Cella; D Scheidegger; K Palmer-Lehmann; P Lane; A Lanzavecchia; G Alber
Journal:  J Exp Med       Date:  1996-08-01       Impact factor: 14.307
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  15 in total

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Authors:  Peter Dias; Francesca Giannoni; Lian Ni Lee; Dongun Han; Sorah Yoon; Hideo Yagita; Miyuki Azuma; Sally R Sarawar
Journal:  J Virol       Date:  2010-06-09       Impact factor: 5.103

2.  CD80 and CD86 control antiviral CD8+ T-cell function and immune surveillance of murine gammaherpesvirus 68.

Authors:  Shinichiro Fuse; Joshua J Obar; Sarah Bellfy; Erica K Leung; Weijun Zhang; Edward J Usherwood
Journal:  J Virol       Date:  2006-09       Impact factor: 5.103

3.  Impact of selective CD28 blockade on virus-specific immunity to a murine Epstein-Barr virus homolog.

Authors:  Rebecca L Crepeau; Joseph A Elengickal; Glenn M La Muraglia; Mandy L Ford
Journal:  Am J Transplant       Date:  2019-03-29       Impact factor: 8.086

4.  CD40 engagement on dendritic cells, but not on B or T cells, is required for long-term control of murine gammaherpesvirus 68.

Authors:  Francesca Giannoni; Ashley Shea; Chandra Inglis; Lian Ni Lee; Sally R Sarawar
Journal:  J Virol       Date:  2008-09-03       Impact factor: 5.103

5.  Differential requirement for CD28 and CD80/86 pathways of costimulation in the long-term control of murine gammaherpesvirus-68.

Authors:  Ashley B Lyon; Sally R Sarawar
Journal:  Virology       Date:  2006-08-24       Impact factor: 3.616

6.  B cell-specific expression of B7-2 is required for follicular Th cell function in response to vaccinia virus.

Authors:  Samira Salek-Ardakani; Youn Soo Choi; Mohammed Rafii-El-Idrissi Benhnia; Rachel Flynn; Ramon Arens; Stephen Shoenberger; Shane Crotty; Michael Croft; Shahram Salek-Ardakani
Journal:  J Immunol       Date:  2011-03-25       Impact factor: 5.422

7.  CD8+ T cell dysfunction and increase in murine gammaherpesvirus latent viral burden in the absence of 4-1BB ligand.

Authors:  Shinichiro Fuse; Sarah Bellfy; Hideo Yagita; Edward J Usherwood
Journal:  J Immunol       Date:  2007-04-15       Impact factor: 5.422

8.  Preferential use of B7.2 and not B7.1 in priming of vaccinia virus-specific CD8 T cells.

Authors:  Shahram Salek-Ardakani; Ramon Arens; Rachel Flynn; Alessandro Sette; Stephen P Schoenberger; Michael Croft
Journal:  J Immunol       Date:  2009-03-01       Impact factor: 5.422

9.  Primary clearance of murine gammaherpesvirus 68 by PKCtheta-/- CD8 T cells is compromised in the absence of help from CD4 T cells.

Authors:  Peter Dias; Ashley L Shea; Chandra Inglis; Francesca Giannoni; Lian Ni Lee; Sally R Sarawar
Journal:  J Virol       Date:  2008-09-25       Impact factor: 5.103

10.  Perturbation of lytic and latent gammaherpesvirus infection in the absence of the inhibitory receptor CEACAM1.

Authors:  Heiko Adler; Susanne El-Gogo; Simone Guggemoos; Wolfgang Zimmermann; Nicole Beauchemin; Robert Kammerer
Journal:  PLoS One       Date:  2009-07-21       Impact factor: 3.240
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