AIMS: To assess maternal compliance with nutritional recommendations in an allergy preventive programme, and identify factors influencing compliance behaviour. METHODS: Randomised double-blind intervention study on the effect of infant formulas with reduced allergenicity in healthy, term newborns at risk of atopy. Maternal compliance with dietary recommendations concerning milk and solid food feeding was categorised. RESULTS: A total of 2252 newborns were randomised to one of four study formulas. The drop out rate during the first year of life was 13.5% (n = 304). The rates of high, medium, and low compliance to milk feeding during weeks 1-16 were 83.4%, 4.0%, and 7.5%; the corresponding rates to solid food feeding during weeks 1-24 were 60.0%, 12.1%, and 22.9%. In 5.1% of subjects no nutritional information was available. Low compliance was more frequent among non-German parents, parents with a low level of education, young mothers, smoking mothers, and those who weaned their infant before the age of 2 months. CONCLUSIONS: Evaluation of allergy preventive programmes should take into account non-compliance for assessing the preventive effectiveness on study outcome.
RCT Entities:
AIMS: To assess maternal compliance with nutritional recommendations in an allergy preventive programme, and identify factors influencing compliance behaviour. METHODS: Randomised double-blind intervention study on the effect of infant formulas with reduced allergenicity in healthy, term newborns at risk of atopy. Maternal compliance with dietary recommendations concerning milk and solid food feeding was categorised. RESULTS: A total of 2252 newborns were randomised to one of four study formulas. The drop out rate during the first year of life was 13.5% (n = 304). The rates of high, medium, and low compliance to milk feeding during weeks 1-16 were 83.4%, 4.0%, and 7.5%; the corresponding rates to solid food feeding during weeks 1-24 were 60.0%, 12.1%, and 22.9%. In 5.1% of subjects no nutritional information was available. Low compliance was more frequent among non-German parents, parents with a low level of education, young mothers, smoking mothers, and those who weaned their infant before the age of 2 months. CONCLUSIONS: Evaluation of allergy preventive programmes should take into account non-compliance for assessing the preventive effectiveness on study outcome.
Authors: B Laubereau; B Filipiak-Pittroff; A von Berg; A Grübl; D Reinhardt; H E Wichmann; S Koletzko Journal: Arch Dis Child Date: 2004-11 Impact factor: 3.791
Authors: A von Berg; B Filipiak-Pittroff; H Schulz; U Hoffmann; E Link; M Sußmann; M Schnappinger; I Brüske; M Standl; U Krämer; B Hoffmann; J Heinrich; C-P Bauer; S Koletzko; D Berdel Journal: Allergy Date: 2015-11-23 Impact factor: 13.146
Authors: A von Berg; B Filipiak-Pittroff; U Krämer; E Link; J Heinrich; S Koletzko; A Grübl; U Hoffmann; C Beckmann; D Reinhardt; C P Bauer; E Wichmann; D Berdel Journal: Allergol Select Date: 2017-08-04
Authors: Sue Jordan; Alan Watkins; Mel Storey; Steven J Allen; Caroline J Brooks; Iveta Garaiova; Martin L Heaven; Ruth Jones; Sue F Plummer; Ian T Russell; Catherine A Thornton; Gareth Morgan Journal: PLoS One Date: 2013-07-09 Impact factor: 3.240