Literature DB >> 11860150

Corticotropin-releasing hormone affects cytokine production in human HaCaT keratinocytes.

Blazej Zbytek1, Andrzej Mysliwski, Andrzej Slominski, Jacobo Wortsman, Edward T Wei, Jolanta Mysliwska.   

Abstract

CRH cutaneous expression is significantly enhanced after exposure to various stimuli (Physiol Rev 2000, 80;979-1020). We evaluated the effect of CRH on cytokine production in HaCaT keratinocytes, a cell line shown to express CRH receptors coupled to cAMP activation and calcium-dependent transmission pathways. It is demonstrated for the first time that exogenously added CRH stimulates production of IL-6 and IL-11. It also inhibits production of IL-1beta and does not affect TNF-alpha production. Our results indicate that CRH function(s) during cutaneous stress may be mediated by differential effects on cytokine production.

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Year:  2002        PMID： 11860150     DOI： 10.1016/s0024-3205(01)01476-x

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  23 in total

1.  CRH functions as a growth factor/cytokine in the skin.

Authors:  A Slominski; B Zbytek; A Pisarchik; R M Slominski; M A Zmijewski; J Wortsman
Journal:  J Cell Physiol       Date:  2006-03       Impact factor: 6.384

Review 2.  Corticotropin releasing hormone and the skin.

Authors:  Andrzej Slominski; Blazej Zbytek; Michal Zmijewski; Radomir M Slominski; Sobia Kauser; Jacobo Wortsman; Desmond J Tobin
Journal:  Front Biosci       Date:  2006-09-01

3.  Neuroendocrinology of the skin: An overview and selective analysis.

Authors:  Michal A Zmijewski; Andrzej T Slominski
Journal:  Dermatoendocrinol       Date:  2011-01

4.  Inhibiting interleukin-18 production through the mitogen-activated protein kinase pathway, a potential role of corticotropin-releasing hormone in chronic plaque psoriasis.

Authors:  Chun-Lei Zhou; Xiao-Jing Yu; Da-Xing Cai; Yong-Hao Xu; Chun-Yang Li; Qing Sun
Journal:  Inflammation       Date:  2015       Impact factor: 4.092

Review 5.  Stress-related skin disorders.

Authors:  Alex Alexopoulos; George P Chrousos
Journal:  Rev Endocr Metab Disord       Date:  2016-09       Impact factor: 6.514

Review 6.  Sensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine system.

Authors:  Andrzej T Slominski; Michal A Zmijewski; Cezary Skobowiat; Blazej Zbytek; Radomir M Slominski; Jeffery D Steketee
Journal:  Adv Anat Embryol Cell Biol       Date:  2012       Impact factor: 1.231

7.  Corticotropin-releasing hormone triggers differentiation in HaCaT keratinocytes.

Authors:  B Zbytek; M Pikula; R M Slominski; A Mysliwski; E Wei; J Wortsman; A T Slominski
Journal:  Br J Dermatol       Date:  2005-03       Impact factor: 9.302

8.  On the role of the corticotropin-releasing hormone signalling system in the aetiology of inflammatory skin disorders.

Authors:  A Slominski
Journal:  Br J Dermatol       Date:  2009-02       Impact factor: 9.302

9.  Corticotropin-releasing hormone inhibits nuclear factor-kappaB pathway in human HaCaT keratinocytes.

Authors:  Blazej Zbytek; Lawrence M Pfeffer; Andrzej T Slominski
Journal:  J Invest Dermatol       Date:  2003-12       Impact factor: 8.551

10.  Corticotropin-releasing hormone stimulates NF-kappaB in human epidermal keratinocytes.

Authors:  Blazej Zbytek; Lawrence M Pfeffer; Andrzej T Slominski
Journal:  J Endocrinol       Date:  2004-06       Impact factor: 4.286
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