Literature DB >> 11859011

Cytotoxic, antifouling bromotyramines: a synthetic study on simple marine natural products and Their analogues.

Ryan C Schoenfeld1, Susan Conova, Daniel Rittschof, Bruce Ganem.   

Abstract

Synthesis and biological evaluation of two naturally-occurring bromotyramines, moloka'iamine 1 and 3,5-dibromo-4-methoxy-beta-phenethylamine 2, together with several analogues, have been completed. Bromotyramine 2 is cytotoxic, and was found to be a potent antifoulant. Analogues 15 and 16 also displayed significant cytotoxic and antifouling activities.

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Year:  2002        PMID： 11859011     DOI： 10.1016/s0960-894x(02)00022-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

Review 1.  The marine bromotyrosine derivatives.

Authors:  Jiangnan Peng; Jing Li; Mark T Hamann
Journal:  Alkaloids Chem Biol       Date:  2005

2.  Structural activity relationship studies of zebra mussel antifouling and antimicrobial agents from verongid sponges.

Authors:  Jeffrey A Diers; Hari Kishore Pennaka; Jiangnan Peng; John J Bowling; Stephen O Duke; Mark T Hamann
Journal:  J Nat Prod       Date:  2004-12       Impact factor: 4.050

3.  Design, synthesis and biological evaluation of ezrin inhibitors targeting metastatic osteosarcoma.

Authors:  Mikell Paige; George Kosturko; Güllay Bulut; Matthew Miessau; Said Rahim; Jeffrey A Toretsky; Milton L Brown; Aykut Üren
Journal:  Bioorg Med Chem       Date:  2013-11-14       Impact factor: 3.641

4.  Searching for "environmentally-benign" antifouling biocides.

Authors:  Yan Ting Cui; Serena L M Teo; Wai Leong; Christina L L Chai
Journal:  Int J Mol Sci       Date:  2014-05-26       Impact factor: 5.923
  4 in total

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