Literature DB >> 11859001

Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor.

Sabine Barbey1, Laurence Goossens, Thierry Taverne, Joséphine Cornet, Valérie Choesmel, Céline Rouaud, Gilles Gimeno, Sylvie Yannic-Arnoult, Catherine Michaux, Caroline Charlier, Raymond Houssin, Jean Pierre Hénichart.   

Abstract

Dual COX-2/5-LO inhibitors are described as potential new therapeutic agents for inflammatory diseases. A surprisingly potent effect of a 5-LO pharmacophoric group on the COX-2 inhibition is presented as well as pharmacological in vitro and in vivo results.

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Year:  2002        PMID： 11859001     DOI： 10.1016/s0960-894x(02)00013-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  Rationally designed multitarget agents against inflammation and pain.

Authors:  S H Hwang; A T Wecksler; K Wagner; B D Hammock
Journal:  Curr Med Chem       Date:  2013       Impact factor: 4.530

2.  Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase.

Authors:  Sung Hee Hwang; Karen M Wagner; Christophe Morisseau; Jun-Yan Liu; Hua Dong; Aaron T Wecksler; Bruce D Hammock
Journal:  J Med Chem       Date:  2011-04-05       Impact factor: 7.446

3.  In Vitro Antimalarial Activity of Inhibitors of the Human GTPase Rac1.

Authors:  Sarah D'Alessandro; Anna Olivieri; Silvia Parapini; Silvio Paone; Emanuela Erba; Loredana Cavicchini; Manoochehr Pourshaban; Francesco Celani; Alessandro Contini
Journal:  Antimicrob Agents Chemother       Date:  2021-11-01       Impact factor: 5.191
  3 in total

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