| Literature DB >> 11858997 |
Thomas E Renau1, Roger Léger, Rose Yen, Miles W She, Eric M Flamme, Joan Sangalang, Carla L Gannon, Suzanne Chamberland, Olga Lomovskaya, Ving J Lee.
Abstract
Several classes of peptidomimetics of the efflux pump inhibitor D-ornithine-D-homophenylalanine-3-aminoquinoline (MC-02,595) have been prepared and evaluated for their ability to potentiate the activity of the fluoroquinolone levofloxacin in Pseudomonas aeruginosa. A number of the new analogues were as active or more active than the lead, demonstrating that a peptide backbone is not essential for activity.Entities:
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Year: 2002 PMID： 11858997 DOI： 10.1016/s0960-894x(02)00006-9
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823