Literature DB >> 11858991

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. Part 7: structure-activity studies of bicyclic 2-pyridone-containing peptidomimetics.

Peter S Dragovich1, Thomas J Prins, Ru Zhou, Theodore O Johnson, Edward L Brown, Fausto C Maldonado, Shella A Fuhrman, Leora S Zalman, Amy K Patick, David A Matthews, Xinjun Hou, James W Meador, Rose Ann Ferre, Stephen T Worland.   

Abstract

The structure-based design, chemical synthesis, and biological evaluation of bicyclic 2-pyridone-containing human rhinovirus (HRV) 3C protease (3CP) inhibitors are described. An optimized compound is shown to exhibit antiviral activity when tested against a variety of HRV serotypes (EC(50)'s ranging from 0.037 to 0.162 microM).

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 11858991     DOI： 10.1016/s0960-894x(02)00008-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Peptidyl aldehyde NK-1.8k suppresses enterovirus 71 and enterovirus 68 infection by targeting protease 3C.

Authors:  Yaxin Wang; Ben Yang; Yangyang Zhai; Zheng Yin; Yuna Sun; Zihe Rao
Journal:  Antimicrob Agents Chemother       Date:  2015-02-17       Impact factor: 5.191

2.  In vitro antiviral activity and single-dose pharmacokinetics in humans of a novel, orally bioavailable inhibitor of human rhinovirus 3C protease.

Authors:  Amy K Patick; Mary A Brothers; Fausto Maldonado; Susan Binford; Oscar Maldonado; Shella Fuhrman; Annkatrin Petersen; George J Smith; Leora S Zalman; Leigh Ann Burns-Naas; Jonathan Q Tran
Journal:  Antimicrob Agents Chemother       Date:  2005-06       Impact factor: 5.191

3.  A selective intramolecular 5-exo-dig or 6-endo-dig cyclization en route to 2-furanone or 2-pyrone containing tricyclic scaffolds.

Authors:  Christoffer Bengtsson; Fredrik Almqvist
Journal:  J Org Chem       Date:  2011-10-31       Impact factor: 4.354

4.  Synthesis and antimicrobial evaluation of some novel thiazole, pyridone, pyrazole, chromene, hydrazone derivatives bearing a biologically active sulfonamide moiety.

Authors:  Elham S Darwish; Azza M Abdel Fattah; Fawzy A Attaby; Oqba N Al-Shayea
Journal:  Int J Mol Sci       Date:  2014-01-17       Impact factor: 5.923

5.  Ti-superoxide catalyzed oxidative amidation of aldehydes with saccharin as nitrogen source: synthesis of primary amides.

Authors:  Rohit B Kamble; Kishor D Mane; Bapurao D Rupanawar; Pranjal Korekar; A Sudalai; Gurunath Suryavanshi
Journal:  RSC Adv       Date:  2020-01-02       Impact factor: 4.036

6.  Studies on Inhibition of Proliferation of Enterovirus-71 by Compound YZ-LY-0.

Authors:  Qingzhan Yang; Qing Jie; Neil Shaw; Lei Li; Zihe Rao; Zheng Yin; Zhiyong Lou
Journal:  Int J Biol Sci       Date:  2015-11-01       Impact factor: 6.580

7.  Synthetic studies towards anti-SARS agents: application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate.

Authors:  Shu-Sin Chng; Truong-Giang Hoang; Wei-Woon Wayne Lee; Mun-Pun Tham; Hui Yvonne Ling; Teck-Peng Loh
Journal:  Tetrahedron Lett       Date:  2004-11-11       Impact factor: 2.415

Review 8.  The human rhinovirus: human-pathological impact, mechanisms of antirhinoviral agents, and strategies for their discovery.

Authors:  Judith M Rollinger; Michaela Schmidtke
Journal:  Med Res Rev       Date:  2011-01       Impact factor: 12.944

9.  Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase.

Authors:  Keqiang Fan; Ping Wei; Qian Feng; Sidi Chen; Changkang Huang; Liang Ma; Bing Lai; Jianfeng Pei; Ying Liu; Jianguo Chen; Luhua Lai
Journal:  J Biol Chem       Date:  2003-10-15       Impact factor: 5.157
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.