| Literature DB >> 11858990 |
George A Doherty1, Theodore Kamenecka, Ermenegilda McCauley, Gail Van Riper, Richard A Mumford, Sharon Tong, William K Hagmann.
Abstract
A series of N-arylated phenylalanine derivatives has been synthesized and has been shown to be potent inhibitors of the integrin VLA-4. N-phenyl and N-heteroaryl derivatives with hydrogen bond acceptors in the meta position demonstrated low nanomolar activity against VLA-4.Entities:
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Year: 2002 PMID： 11858990 DOI： 10.1016/s0960-894x(02)00009-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823