| Literature DB >> 11858848 |
Nilda M Silva1, Jorge L M Tributino, Ana L P Miranda, Eliezer J Barreiro, Carlos A M Fraga.
Abstract
In this work we report the synthesis and evaluation of the analgesic properties of new isosteric heterocyclic derivatives, presenting the isoxazole nucleus, designed as nicotinic acetylcholine receptor ligand candidates, analogues to alkaloid epibatidine. Compound 2-(3-methyl-5-isoxazolyl)pyridine (3) presented the best analgesic profile of this series in hot plate test, which was partially prevented by pretreatment with nicotinic receptor antagonist mecamylamine.Entities:
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Year: 2002 PMID： 11858848 DOI： 10.1016/s0223-5234(01)01327-7
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514