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Literature DB >> 11858759

Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata.

Deniz Tasdemir¹, Gina C Mangalindan, Gisela P Concepción, Sheryl M Verbitski, Sridhar Rabindran, Miriam Miranda, Michael Greenstein, John N A Hooper, Mary Kay Harper, Chris M Ireland.

Abstract

Two new isomalabaricane triterpenes, stellettin H (1) and stellettin I (2), have been isolated from the marine sponge Rhabdastrella globostellata, collected from the Philippines. Stellettins A-D (3-6), (-)-stellettin E (7), and rhabdastrellic acid-A (8) were also isolated and characterized. Stellettin B (4) and (-)-stellettin E (7) showed selective cytotoxicity toward p21(WAF1/Cip1)-deficient human colon tumor (HCT-116) cells with IC(50) values of 0.043 and 0.039 microM, respectively.

Entities: Chemical Disease Gene Species

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Year: 2002 PMID： 11858759 DOI： 10.1021/np0104020

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

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Cited

17 in total

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Authors: Dirk Erpenbeck; Rob W M van Soest
Journal: Mar Biotechnol (NY) Date: 2006-07-03 Impact factor: 3.619

2. Natural products reveal cancer cell dependence on oxysterol-binding proteins.

Authors: Anthony W G Burgett; Thomas B Poulsen; Kittikhun Wangkanont; D Ryan Anderson; Chikako Kikuchi; Kousei Shimada; Shuichi Okubo; Kevin C Fortner; Yoshihiro Mimaki; Minpei Kuroda; Jason P Murphy; David J Schwalb; Eugene C Petrella; Ivan Cornella-Taracido; Markus Schirle; John A Tallarico; Matthew D Shair
Journal: Nat Chem Biol Date: 2011-08-07 Impact factor: 15.040

3. Application of diffusion growth chambers for the cultivation of marine sponge-associated bacteria.

Authors: Georg Steinert; Susanna Whitfield; Michael W Taylor; Carsten Thoms; Peter J Schupp
Journal: Mar Biotechnol (NY) Date: 2014-05-17 Impact factor: 3.619

4. Culturable bacterial symbionts isolated from two distinct sponge species (Pseudoceratina clavata and Rhabdastrella globostellata) from the Great Barrier Reef display similar phylogenetic diversity.

Authors: Feras F Lafi; Mary J Garson; John A Fuerst
Journal: Microb Ecol Date: 2005-10-15 Impact factor: 4.552

5. Bioactive isomalabaricane triterpenoids from Rhabdastrella globostellata that stabilize the binding of DNA polymerase beta to DNA.

Authors: Jason A Clement; Mei Li; Sidney M Hecht; David G I Kingston
Journal: J Nat Prod Date: 2006-03 Impact factor: 4.050

Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata.

Review 1. Status and perspective of sponge chemosystematics.

2. Natural products reveal cancer cell dependence on oxysterol-binding proteins.

3. Application of diffusion growth chambers for the cultivation of marine sponge-associated bacteria.

4. Culturable bacterial symbionts isolated from two distinct sponge species (Pseudoceratina clavata and Rhabdastrella globostellata) from the Great Barrier Reef display similar phylogenetic diversity.

5. Bioactive isomalabaricane triterpenoids from Rhabdastrella globostellata that stabilize the binding of DNA polymerase beta to DNA.

6. Synthesis of amide isosteres of schweinfurthin-based stilbenes.

7. Geoditin A induces oxidative stress and apoptosis on human colon HT29 cells.

Review 8. Bioactive sesterterpenes and triterpenes from marine sponges: occurrence and pharmacological significance.

9. Rhabdastrellic acid-A induced autophagy-associated cell death through blocking Akt pathway in human cancer cells.

Review 10. Malabaricane and Isomalabaricane Triterpenoids, Including Their Glycoconjugated Forms.