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Literature DB >> 11858757

Achyrofuran, a new antihyperglycemic dibenzofuran from the South American medicinal plant Achyrocline satureioides.

John R Carney¹, Joann M Krenisky, R Thomas Williamson, Jian Luo.

Abstract

A new prenylated dibenzofuran, achyrofuran (2), was isolated from an extract of Achyrocline satureioides by bioassay-guided fractionation using the db/db mouse model for type 2 diabetes. Compound 2significantly lowered blood glucose levels in this model when administered orally at 20 mg/kg q.d.

Entities: Chemical Disease Species

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Year: 2002 PMID： 11858757 DOI： 10.1021/np010374l

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

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Cited

6 in total

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Authors: Sabrina Heng; Katharine M Harris; Evan R Kantrowitz
Journal: Eur J Med Chem Date: 2010-01-13 Impact factor: 6.514

2. Naphthalenemethyl ester derivative of dihydroxyhydrocinnamic acid, a component of cinnamon, increases glucose disposal by enhancing translocation of glucose transporter 4.

Authors: W Kim; L Y Khil; R Clark; S H Bok; E E Kim; S Lee; H S Jun; J W Yoon
Journal: Diabetologia Date: 2006-08-09 Impact factor: 10.122

3. Synergistic effect of surfactin from Bacillus subtilis C4 and Achyrocline satureioides extracts on the viability of Paenibacillus larvae.

Authors: D C Sabaté; M J Gonzaléz; M P Porrini; M J Eguaras; M C Audisio; J M Marioli
Journal: World J Microbiol Biotechnol Date: 2011-11-12 Impact factor: 3.312

Achyrofuran, a new antihyperglycemic dibenzofuran from the South American medicinal plant Achyrocline satureioides.

1. Designing inhibitors against fructose 1,6-bisphosphatase: exploring natural products for novel inhibitor scaffolds.

2. Naphthalenemethyl ester derivative of dihydroxyhydrocinnamic acid, a component of cinnamon, increases glucose disposal by enhancing translocation of glucose transporter 4.

3. Synergistic effect of surfactin from Bacillus subtilis C4 and Achyrocline satureioides extracts on the viability of Paenibacillus larvae.

4. (1-bromovinyl)-MIDA boronate: a readily accessible and highly versatile building block for small molecule synthesis.

5. Indigenous traditional medicine: in vitro anti-giardial activity of plants used in the treatment of diarrhea.

6. RECENT SYNTHETIC DEVELOPMENTS AND APPLICATIONS OF THE ULLMANN REACTION. A REVIEW.