Literature DB >> 11858661

CJ-15,801, a novel antibiotic from a fungus, Seimatosporium sp.

Y Sugie1, K A Dekker, H Hirai, T Ichiba, M Ishiguro, Y Shiomi, A Sugiura, L Brennan, J Duignan, L H Huang, J Sutcliffe, Y Kojima.   

Abstract

A novel antibiotic, CJ-15,801 (I), was isolated from the fermentation broth of a fungus, Seimatosporium sp. CL28611. The structure was determined to be a pantothenic acid analog having an alpha,beta-unsaturated carboxylic acid moiety by spectroscopic analyses. The compound inhibits the growth of multi-drug resistant (MDR) Staphylococcus aureus strains with MIC ranging from 6.25 to 50 microg/ml.

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Year:  2001        PMID: 11858661     DOI: 10.7164/antibiotics.54.1060

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  7 in total

1.  The antibiotic CJ-15,801 is an antimetabolite that hijacks and then inhibits CoA biosynthesis.

Authors:  Renier van der Westhuyzen; Justin C Hammons; Jordan L Meier; Samira Dahesh; Wessel J A Moolman; Stephen C Pelly; Victor Nizet; Michael D Burkart; Erick Strauss
Journal:  Chem Biol       Date:  2012-05-25

2.  Flavin-Dependent Monooxygenases NotI and NotI' Mediate Spiro-Oxindole Formation in Biosynthesis of the Notoamides.

Authors:  Amy E Fraley; Hong T Tran; Samantha P Kelly; Sean A Newmister; Ashootosh Tripathi; Hikaru Kato; Sachiko Tsukamoto; Lei Du; Shengying Li; Robert M Williams; David H Sherman
Journal:  Chembiochem       Date:  2020-05-14       Impact factor: 3.164

3.  Antimicrobial activity of pantothenol against staphylococci possessing a prokaryotic type II pantothenate kinase.

Authors:  Shigeru Chohnan; Misa Murase; Kota Kurikawa; Kodai Higashi; Yuta Ogata
Journal:  Microbes Environ       Date:  2014-04-22       Impact factor: 2.912

4.  Computational study of the mechanism and selectivity of ruthenium-catalyzed hydroamidations of terminal alkynes.

Authors:  Bholanath Maity; Lukas J Gooßen; Debasis Koley
Journal:  Chem Sci       Date:  2015-02-18       Impact factor: 9.825

Review 5.  Vitamin in the Crosshairs: Targeting Pantothenate and Coenzyme A Biosynthesis for New Antituberculosis Agents.

Authors:  Hailey S Butman; Timothy J Kotzé; Cynthia S Dowd; Erick Strauss
Journal:  Front Cell Infect Microbiol       Date:  2020-12-15       Impact factor: 5.293

Review 6.  Pantothenate and CoA biosynthesis in Apicomplexa and their promise as antiparasitic drug targets.

Authors:  Laura E de Vries; Matteo Lunghi; Aarti Krishnan; Taco W A Kooij; Dominique Soldati-Favre
Journal:  PLoS Pathog       Date:  2021-12-30       Impact factor: 6.823

7.  Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801.

Authors:  Riyad Domingo; Renier van der Westhuyzen; Anton R Hamann; Konrad J Mostert; Leanne Barnard; Tanya Paquet; Erick T Tjhin; Kevin J Saliba; Willem A L van Otterlo; Erick Strauss
Journal:  Medchemcomm       Date:  2019-10-17       Impact factor: 3.597

  7 in total

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