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Literature DB >> 11856487

Antitumor effect of an adeno-associated virus vector containing the human interferon-beta gene on experimental intracranial human glioma.

Jun Yoshida¹, Masaaki Mizuno, Norimoto Nakahara, Peter Colosi.

Abstract

We constructed an adeno-associated virus (AAV) vector containing the human interferon-beta (HuIFN-b ) gene (AAV-IFN-beta) and investigated its antitumor effect against human glioma cells (U251-SP) inoculated into the brain of nude mice. Prior to this, we examined human glioma cells transduced with AAV-IFN-beta using video-enhanced contrast differential interference contrast (VEC-DIC) microscopy. Infection of AAV-IFN-beta induced apoptosis and secondary necrosis in human glioma cells. In in vivo experiments, we confirmed production of HuIFN-beta and induction of heat-shock protein (HSP) in glioma cells transduced with AAV-IFN-beta. Growth of the experimental gliomas was completely inhibited by six injections of AAV-IFN-beta, starting 7 days after transplantation of glioma cells. In addition, the survival of mice treated with AAV-IFN-beta was remarkably prolonged. These results indicate that AAV-IFN-beta induces apoptosis of glioma cells and has a strong antitumor effect in this experimental glioma model.

Entities: Chemical Disease Gene Species

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Year: 2002 PMID： 11856487 PMCID： PMC5926956 DOI： 10.1111/j.1349-7006.2002.tb01262.x

Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050

15 in total

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6. Gene therapy against an experimental glioma using adeno-associated virus vectors.

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9. Long-term follow-up results of 175 patients with malignant glioma: importance of radical tumour resection and postoperative adjuvant therapy with interferon, ACNU and radiation.

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13 in total

Review 1. Adeno-associated virus vectors: potential applications for cancer gene therapy.

Authors: Chengwen Li; Dawn E Bowles; Terry van Dyke; Richard Jude Samulski
Journal: Cancer Gene Ther Date: 2005-12 Impact factor: 5.987

2. Improved Adeno-associated Viral Gene Transfer to Murine Glioma.

Authors: I Zolotukhin; D Luo; Os Gorbatyuk; Be Hoffman; Kh Warrington; Rw Herzog; Jk Harrison; O Cao
Journal: J Genet Syndr Gene Ther Date: 2013-04-29

Review 3. Gene therapy and targeted toxins for glioma.

Authors: Maria G Castro; Marianela Candolfi; Kurt Kroeger; Gwendalyn D King; James F Curtin; Kader Yagiz; Yohei Mineharu; Hikmat Assi; Mia Wibowo; A K M Ghulam Muhammad; David Foulad; Mariana Puntel; Pedro R Lowenstein
Journal: Curr Gene Ther Date: 2011-06 Impact factor: 4.391

Antitumor effect of an adeno-associated virus vector containing the human interferon-beta gene on experimental intracranial human glioma.

1. Process of apoptosis induced by TNF-alpha in murine fibroblast Ltk-cells: continuous observation with video enhanced contrast microscopy.

2. Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression.

3. [Anti-tumor activity of human recombinant TNF against human malignant glioma cell lines and combined effect with Hu INF-beta].

4. A linear Lowry--Folin assay for both water-soluble and sodium dodecyl sulfate-solubilized proteins.

5. Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells.

6. Gene therapy against an experimental glioma using adeno-associated virus vectors.

7. Clinical effect of interferon in malignant brain tumours.

8. Absence of IFNA and IFNB genes from human malignant glioma cell lines and lack of correlation with cellular sensitivity to interferons.

9. Long-term follow-up results of 175 patients with malignant glioma: importance of radical tumour resection and postoperative adjuvant therapy with interferon, ACNU and radiation.

10. Chromosome 9 deletion mapping reveals interferon alpha and interferon beta-1 gene deletions in human glial tumors.

Review 1. Adeno-associated virus vectors: potential applications for cancer gene therapy.

2. Improved Adeno-associated Viral Gene Transfer to Murine Glioma.

Review 3. Gene therapy and targeted toxins for glioma.

Review 4. Gene therapy and targeted toxins for glioma.

5. Targeting human glioblastoma cells: comparison of nine viruses with oncolytic potential.

6. Enhancers of adeno-associated virus AAV2 transduction via high throughput siRNA screening.

7. Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficits.

8. Directed evolution of adeno-associated virus for glioma cell transduction.

Review 9. Gene therapy as an adjuvant treatment for malignant gliomas: from bench to bedside.

10. Preventing growth of brain tumors by creating a zone of resistance.