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Literature DB >> 11856068

Pathophysiological tissue changes associated with repetitive movement: a review of the evidence.

Abstract

Work-related musculoskeletal disorders (WMSDs) represent approximately one third of workers' compensation costs in US private industry, yet estimates of acceptable exposure levels for forceful and repetitive tasks are imprecise, in part, due to lack of measures of tissue injury in humans. In this review, the authors discuss the scope of upper-extremity WMSDs, the relationship between repetition rate and forcefulness of reaching tasks and WMSDs, cellular responses to injury in vivo and in vitro, and animal injury models of repetitive, forceful tasks. The authors describe a model using albino rats and present evidence related to tissue injury and inflammation due to a highly repetitive reaching task. A conceptual schematic for WMSD development and suggestions for further research are presented. Animal models can enhance our ability to predict risk and to manage WMSDs in humans because such models permit the direct observation of exposed tissues as well as motor behavior.

Entities: Disease Species

Mesh：

Year: 2002 PMID： 11856068 PMCID： PMC1550512 DOI： 10.1093/ptj/82.2.173

Source DB: PubMed Journal: Phys Ther ISSN： 0031-9023

121 in total

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38 in total

1. VGluT2 and NMDAR1 expression in cells in the inflammatory infiltrates in experimentally induced myositis: evidence of local glutamate signaling suggests autocrine/paracrine effects in an overuse injury model.

Authors: Christoph Spang; Alexander Scott; Patrik Danielson; Ronny Lorentzon; Sture Forsgren
Journal: Inflammation Date: 2012-02 Impact factor: 4.092

Pathophysiological tissue changes associated with repetitive movement: a review of the evidence.

1. Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma.

Review 2. Gender and neurogenic variables in tendon biology and repetitive motion disorders.

3. Median sensory distal amplitude and latency: comparisons between nonexposed managerial/professional employees and industrial workers.

4. Management of upper extremity cumulative trauma disorders.

Review 5. Protein synthesis and the heart shock/stress response after ischemia.

6. 99Tcm-MDP blood-pool phase in the assessment of repetitive strain injury.

7. Hyperthermia protects against light damage in the rat retina.

Review 8. A conceptual model for work-related neck and upper-limb musculoskeletal disorders.

9. Cytokine suppressive anti-inflammatory compounds inhibit bone resorption in vitro.

10. Occupational upper extremity disorders in the federal workforce. Prevalence, health care expenditures, and patterns of work disability.

1. VGluT2 and NMDAR1 expression in cells in the inflammatory infiltrates in experimentally induced myositis: evidence of local glutamate signaling suggests autocrine/paracrine effects in an overuse injury model.

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5. Bone loss from high repetitive high force loading is prevented by ibuprofen treatment.

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