| Literature DB >> 11855978 |
Kiyosei Takasu1, Hiroshi Inoue, Hye-Sook Kim, Makoto Suzuki, Tadao Shishido, Yusuke Wataya, Masataka Ihara.
Abstract
The rhodacyanine dye MKT-077 (1), a potent antitumor agent, was found to possess strong in vitro activity against Plasmodium falciparum and a low cytotoxicity. Several new rhodacyanine dyes related to 1, containing a variety of linked heterocyclic moieties, were synthesized, and their antimalarial potencies were evaluated. The synthetic rhodacyanines were found to have EC(50) values against P. falciparum in vitro in the range of 4-300 nM. Several compounds in this series have remarkable selective toxicity profiles (>100).Entities:
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Year: 2002 PMID： 11855978 DOI： 10.1021/jm0155704
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446