| Literature DB >> 1185578 |
P D Nadkarni, D O Kildsig, P A Kramer, G S Banker.
Abstract
The adhesion of a polymer film to selected tablet substrates was studied. The effect of tablet surface roughness and film-coating solvent on the adhesion of the film to the tablet was determined. A film-coating solvent having a solubility parameter close to that of the polymer was found to produce a stronger adhesional bond than a solvent having a lower surface tension. An increase in tablet surface roughness also increased film adhesion to the tablet. The adhesion was measured as the force required to peel a section of film from the tablet with a stress-strain analyzer.Entities:
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Year: 1975 PMID： 1185578 DOI： 10.1002/jps.2600640931
Source DB: PubMed Journal: J Pharm Sci ISSN： 0022-3549 Impact factor: 3.534