| Literature DB >> 11855632 |
K Tanaka1, H Minagawa, M F Xie, Y Yanagi.
Abstract
Signaling lymphocyte activation molecule (SLAM), a cellular receptor for measles virus, was downregulated from the surface of cells infected with either the Edmonston or wild-type KA strain of measles virus. Transfection of the expression plasmid encoding the Edmonston or KA hemagglutinin, but not the fusion protein, induced downregulation of SLAM in not only cells expressing the envelope protein on the surface, but those not expressing it. After cocultivation with cells expressing the hemagglutinin, SLAM-expressing cells also exhibited downregulation of SLAM. Thus, the measles virus hemagglutinin can induce downregulation of SLAM in cells either expressing or coming in contact with it.Entities:
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Year: 2002 PMID： 11855632 DOI： 10.1007/s705-002-8312-0
Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574