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Literature DB >> 11854259

Selective T-cell recognition of the N-terminal peptide of GroES in tuberculosis.

Boosbun Chua-Intra¹, Robert J Wilkinson, Juraj Ivanyi.

Abstract

Peptides derived from the whole sequence of mycobacterial GroES heat shock proteins were tested for the ability to induce the proliferation of blood mononuclear cells from tuberculosis patients and sensitized healthy subjects. The response to the N-terminal peptide (residues 1 to 16) was found to be more frequent and stronger in tuberculosis patients. This finding is exceptional, considering that recognition of all other GroES peptides by patients was either diminished or not different from that of controls.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2002 PMID： 11854259 PMCID： PMC127756 DOI： 10.1128/IAI.70.3.1645-1647.2002

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

13 in total

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Authors: J J Ellner
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2. Enumeration of T cells specific for RD1-encoded antigens suggests a high prevalence of latent Mycobacterium tuberculosis infection in healthy urban Indians.

Authors: A Lalvani; P Nagvenkar; Z Udwadia; A A Pathan; K A Wilkinson; J S Shastri; K Ewer; A V Hill; A Mehta; C Rodrigues
Journal: J Infect Dis Date: 2000-12-21 Impact factor: 5.226

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Authors: F Dieli; M Singh; R Spallek; A Romano; L Titone; G Sireci; G Friscia; C Di Sano; D Santini; A Salerno; J Ivanyi
Journal: Scand J Immunol Date: 2000-07 Impact factor: 3.487

4. Peptide-specific T cell response to Mycobacterium tuberculosis: clinical spectrum, compartmentalization, and effect of chemotherapy.

Authors: R J Wilkinson; H M Vordermeier; K A Wilkinson; A Sjölund; C Moreno; G Pasvol; J Ivanyi
Journal: J Infect Dis Date: 1998-09 Impact factor: 5.226

5. Mycobacterium tuberculosis chaperonin 10 forms stable tetrameric and heptameric structures. Implications for its diverse biological activities.

Authors: G Fossati; P Lucietto; P Giuliani; A R Coates; S Harding; H Cölfen; G Legname; E Chan; A Zaliani; P Mascagni
Journal: J Biol Chem Date: 1995-11-03 Impact factor: 5.157

6. Immunoreactivity of a 10-kDa antigen of Mycobacterium tuberculosis.

Authors: P F Barnes; V Mehra; B Rivoire; S J Fong; P J Brennan; M S Voegtline; P Minden; R A Houghten; B R Bloom; R L Modlin
Journal: J Immunol Date: 1992-03-15 Impact factor: 5.422

7. T cell repertoire in tuberculosis: selective anergy to an immunodominant epitope of the 38-kDa antigen in patients with active disease.

Authors: H M Vordermeier; D P Harris; G Friscia; E Román; H M Surcel; C Moreno; G Pasvol; J Ivanyi
Journal: Eur J Immunol Date: 1992-10 Impact factor: 5.532

Selective T-cell recognition of the N-terminal peptide of GroES in tuberculosis.

1. Pleural fluid and peripheral blood lymphocyte function in tuberculosis.

2. Enumeration of T cells specific for RD1-encoded antigens suggests a high prevalence of latent Mycobacterium tuberculosis infection in healthy urban Indians.

3. Change of Th0 to Th1 cell-cytokine profile following tuberculosis chemotherapy.

4. Peptide-specific T cell response to Mycobacterium tuberculosis: clinical spectrum, compartmentalization, and effect of chemotherapy.

5. Mycobacterium tuberculosis chaperonin 10 forms stable tetrameric and heptameric structures. Implications for its diverse biological activities.

6. Immunoreactivity of a 10-kDa antigen of Mycobacterium tuberculosis.

7. T cell repertoire in tuberculosis: selective anergy to an immunodominant epitope of the 38-kDa antigen in patients with active disease.

8. The GroES homolog of Helicobacter pylori confers protective immunity against mucosal infection in mice.

9. A synthetic 10-kD heat shock protein (hsp10) from Mycobacterium tuberculosis modulates adjuvant arthritis.

10. Interleukin 12 at the site of disease in tuberculosis.

1. Proposing low-similarity peptide vaccines against Mycobacterium tuberculosis.

2. Possible association of GroES and antigen 85 proteins with heat resistance of Mycobacterium paratuberculosis.

3. Meeting Report: NIH Workshop on the Tuberculosis Immune Epitope Database.

Review 4. Function and Potentials of M. tuberculosis Epitopes.