Literature DB >> 11854091

A multilateral effort to develop DNA vaccines against falciparum malaria.

Sanjai Kumar1, Judith E Epstein, Thomas L Richie, Francis K Nkrumah, Lorraine Soisson, Daniel J Carucci, Stephen L Hoffman.   

Abstract

Scientists from several organizations worldwide are working together to develop a multistage, multigene DNA-based vaccine against Plasmodium falciparum malaria. This collaborative vaccine development effort is named Multi-Stage DNA-based Malaria Vaccine Operation. An advisory board of international experts in vaccinology, malariology and field trials provides the scientific oversight to support the operation. This article discusses the rationale for the approach, underlying concepts and the pre-clinical development process, and provides a brief outline of the plans for the clinical testing of a multistage, multiantigen malaria vaccine based on DNA plasmid immunization technology.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 11854091     DOI： 10.1016/s1471-4922(01)02207-3

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  11 in total

Review 1.  Cytokines in the pathogenesis of and protection against malaria.

Authors:  Iñigo Angulo; Manuel Fresno
Journal:  Clin Diagn Lab Immunol       Date:  2002-11

Review 2.  Vaccines for malaria: how close are we?

Authors:  Mahamadou A Thera; Christopher V Plowe
Journal:  Annu Rev Med       Date:  2011-11-10       Impact factor: 13.739

3.  Boosting of DNA vaccine-elicited gamma interferon responses in humans by exposure to malaria parasites.

Authors:  Ruobing Wang; Thomas L Richie; Maria Fe Baraceros; Nancy Rahardjo; Tanya Gay; Jo-Glenna Banania; Yupin Charoenvit; Judith E Epstein; Thomas Luke; Daniel A Freilich; Jon Norman; Stephen L Hoffman
Journal:  Infect Immun       Date:  2005-05       Impact factor: 3.441

Review 4.  Genetic vaccination approaches against malaria based on the circumsporozoite protein.

Authors:  Sandra Scheiblhofer; Richard Weiss; Josef Thalhamer
Journal:  Wien Klin Wochenschr       Date:  2006       Impact factor: 1.704

5.  A bicistronic DNA vaccine containing apical membrane antigen 1 and merozoite surface protein 4/5 can prime humoral and cellular immune responses and partially protect mice against virulent Plasmodium chabaudi adami DS malaria.

Authors:  A Rainczuk; T Scorza; T W Spithill; P M Smooker
Journal:  Infect Immun       Date:  2004-10       Impact factor: 3.441

6.  Novel antigen identification method for discovery of protective malaria antigens by rapid testing of DNA vaccines encoding exons from the parasite genome.

Authors:  Diana Haddad; Erika Bilcikova; Adam A Witney; Jane M Carlton; Charles E White; Peter L Blair; Rana Chattopadhyay; Joshua Russell; Esteban Abot; Yupin Charoenvit; Joao C Aguiar; Daniel J Carucci; Walter R Weiss
Journal:  Infect Immun       Date:  2004-03       Impact factor: 3.441

7.  Induction of specific T-cell responses, opsonizing antibodies, and protection against Plasmodium chabaudi adami infection in mice vaccinated with genomic expression libraries expressed in targeted and secretory DNA vectors.

Authors:  A Rainczuk; T Scorza; P M Smooker; T W Spithill
Journal:  Infect Immun       Date:  2003-08       Impact factor: 3.441

8.  The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum.

Authors:  Zbynek Bozdech; Manuel Llinás; Brian Lee Pulliam; Edith D Wong; Jingchun Zhu; Joseph L DeRisi
Journal:  PLoS Biol       Date:  2003-08-18       Impact factor: 8.029

9.  Ethnodiagnostic skills of the digo community for malaria: a lead to traditional bioprospecting.

Authors:  Joseph Mwanzia Nguta; James M Mbaria; Peter K Gathumbi; Daniel Gakuya; John David Kabasa; Stephen Gitahi Kiama
Journal:  Front Pharmacol       Date:  2011-06-24       Impact factor: 5.810

10.  Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA.

Authors:  Thomas L Richie; Yupin Charoenvit; Ruobing Wang; Judith E Epstein; Richard C Hedstrom; Sanjai Kumar; Thomas C Luke; Daniel A Freilich; Joao C Aguiar; John B Sacci; Martha Sedegah; Ronald A Nosek; Patricia De La Vega; Mara P Berzins; Victoria F Majam; Esteban N Abot; Harini Ganeshan; Nancy O Richie; Jo Glenna Banania; Maria Fe B Baraceros; Tanya G Geter; Robin Mere; Lolita Bebris; Keith Limbach; Bradley W Hickey; David E Lanar; Jennifer Ng; Meng Shi; Peter M Hobart; Jon A Norman; Lorraine A Soisson; Michael R Hollingdale; William O Rogers; Denise L Doolan; Stephen L Hoffman
Journal:  Hum Vaccin Immunother       Date:  2012-11-01       Impact factor: 3.452
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.