Pubertal neurodevelopment and the emergence of psychotic symptoms.

One of the chief epidemiological hallmarks of schizophrenia is its modal age at onset in early adulthood. Clinical onset is preceded by an adolescent period that is usually characterized by increasing adjustment problems. Recent theorizing about the etiology of schizophrenia has focused on postpubertal brain changes that may be involved in triggering the expression of vulnerability for schizophrenia. In this paper, we further examine the normal neurodevelopmental processes that occur in adolescence and the underlying role of hormonal factors in controlling the expression of genes that govern brain maturation. We then consider how postpubertal hormone changes might serve to trigger the expression of vulnerability genes that code for abnormal brain development.