Literature DB >> 1185394

Growth hormone excess and sexual precocity in polyostotic fibrous dysplasia (McCune-Albright syndrome): evidence for abnormal hypothalamic function.

E S Lightner, R Penny, S D Frasier.   

Abstract

A 5-5/12-year-old boy with gigantism and precocious puberty associated with the McCune-Albright syndrome is presented. Serum concentrations of growth hormone were extremely elevated (128-163 ng/ml) and were not suppressed by hyperglycemia or chlorpromazine. Serum LH (7.4 +/- 1.0 SD mIU/ml) and FSH (5.3 +/- 0.3 SD mIU/ml) concentrations were in the range observed in midpuberty. The secretion pattern of LH was episodic. The administration of estradiol suppressed the secretion of FSH and had an apparent positive feedback effect on release of LH. These findings are compatible with abnormal hypothalamic function as the mechanism for the endocrinopathies associated with the McCune-Albright syndrome.

Entities:  

Mesh：

Substances：

Year:  1975        PMID： 1185394     DOI： 10.1016/s0022-3476(75)80906-1

Source DB:  PubMed          Journal:  J Pediatr        ISSN： 0022-3476            Impact factor:   4.406


  10 in total

1.  Gigantism and hyperprolactinemia in polyostotic fibrous dysplasia (Mc Cune--Albright syndrome).

Authors:  C Polychronakos; G Tsoukas; J R Ducharme; J Letarte; R Collu
Journal:  J Endocrinol Invest       Date:  1982 Sep-Oct       Impact factor: 4.256

2.  Octreotide therapy of growth hormone excess in the McCune-Albright syndrome.

Authors:  S I Sherman; P W Ladenson
Journal:  J Endocrinol Invest       Date:  1992-03       Impact factor: 4.256

3.  Acromegaly, multinodular goiter and silent polyostotic fibrous dysplasia. A variant of the McCune-Albright syndrome.

Authors:  R Abs; A Beckers; F L Van de Vyver; A De Schepper; A Stevenaert; G Hennen
Journal:  J Endocrinol Invest       Date:  1990-09       Impact factor: 4.256

4.  Mammosomatotroph hyperplasia associated with acromegaly and hyperprolactinemia in a patient with the McCune-Albright syndrome. A histologic, immunocytologic and ultrastructural study of the surgically-removed adenohypophysis.

Authors:  K Kovacs; E Horvath; M O Thorner; A D Rogol
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1984

5.  McCune-Albright syndrome. A case of primary hypogonadism obscured by hyperprolactinemic hypogonadotropic hypogonadism.

Authors:  A L Swislocki; C A Camargo; A R Hoffman
Journal:  West J Med       Date:  1990-12

6.  McCune-Albright's syndrome.

Authors:  A A Laditan; F Ofodile; K O Osinusi; J O Oluwasanmi
Journal:  J Natl Med Assoc       Date:  1981-12       Impact factor: 1.798

Review 7.  Acromegaly and McCune-Albright syndrome.

Authors:  Sylvie Salenave; Alison M Boyce; Michael T Collins; Philippe Chanson
Journal:  J Clin Endocrinol Metab       Date:  2014-02-11       Impact factor: 5.958

8.  In vitro production of estradiol by ovarian granulosa cells in a case of McCune-Albright syndrome.

Authors:  C Manna; O Epifano; M Riminucci; L Baschieri; M Stefanini; R Canipari
Journal:  J Endocrinol Invest       Date:  1991-04       Impact factor: 4.256

9.  Acromegaly and hyperprolactinemia in a patient with polyostotic fibrous dysplasia: dynamic endocrine studies and treatment with the somatostatin analogue octreotide.

Authors:  M B Garcia; H P Koppeschaar; C J Lips; J H Thijssen; E P Krenning
Journal:  J Endocrinol Invest       Date:  1994-01       Impact factor: 4.256

Review 10.  Clinical Characteristics and Management of Patients With McCune-Albright Syndrome With GH Excess and Precocious Puberty: A Case Series and Literature Review.

Authors:  Xiao Zhai; Lian Duan; Yong Yao; Bing Xing; Kan Deng; Linjie Wang; Feng Feng; Zhiyong Liang; Hui You; Hongbo Yang; Lin Lu; Shi Chen; Renzhi Wang; Hui Pan; Huijuan Zhu
Journal:  Front Endocrinol (Lausanne)       Date:  2021-10-29       Impact factor: 5.555
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.