Literature DB >> 11853921

Transdermal drug delivery of imipramine hydrochloride. I. Effect of terpenes.

Amit Kumar Jain1, Narisetty Sunil Thomas, Ramesh Panchagnula.   

Abstract

The objective of this investigation was to study the effect of different terpenes on IMH permeation in EtOH:W (2:1) system. Permeation studies of IMH were carried out with unjacketed Franz diffusion cells through rat skin. The flux of IMH with terpenes was found to be significantly higher than that in control (EtOH:W, 2:1) (P<0.05). Amongst all studied terpenes, menthol, terpineol, cineole and menthone were found to be effective permeation enhancers for IMH. It was found that the contribution of diffusivity in enhanced permeation of IMH was much higher in comparison to partitioning of IMH in skin with terpene treatment. Results of this study were explained with the help of H-bond breaking potential and self-association of terpenes. In order to elucidate the effect of terpenes on stratum corneum barrier FT-IR was used.

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Year:  2002        PMID： 11853921     DOI： 10.1016/s0168-3659(01)00524-7

Source DB:  PubMed          Journal:  J Control Release        ISSN： 0168-3659            Impact factor:   9.776


  25 in total

1.  Essential oil from Zanthoxylum bungeanum Maxim. and its main components used as transdermal penetration enhancers: a comparative study.

Authors:  Yi Lan; Hui Li; Yan-yan Chen; Ye-wen Zhang; Na Liu; Qing Zhang; Qing Wu
Journal:  J Zhejiang Univ Sci B       Date:  2014-11       Impact factor: 3.066

2.  Magnetophoresis in combination with chemical enhancers for transdermal drug delivery.

Authors:  Srinivasa M Sammeta; Michael A Repka; S Narasimha Murthy
Journal:  Drug Dev Ind Pharm       Date:  2011-03-30       Impact factor: 3.225

3.  Transdermal drug delivery of labetalol hydrochloride: Feasibility and effect of penetration enhancers.

Authors:  Saqib Zafar; Asgar Ali; Mohammed Aqil; Abdul Ahad
Journal:  J Pharm Bioallied Sci       Date:  2010-10

4.  Screening of venlafaxine hydrochloride for transdermal delivery: passive diffusion and iontophoresis.

Authors:  Gursharanjit Singh; Bijaya Ghosh; Dave Kaushalkumar; Vanita Somsekhar
Journal:  AAPS PharmSciTech       Date:  2008-07-01       Impact factor: 3.246

5.  Cytotoxicity and enhancement activity of essential oil from Zanthoxylum bungeanum Maxim. as a natural transdermal penetration enhancer.

Authors:  Yi Lan; Qing Wu; Ying-qiu Mao; Qiong Wang; Jing An; Yan-yan Chen; Wen-ping Wang; Bo-chen Zhao; Na Liu; Ye-wen Zhang
Journal:  J Zhejiang Univ Sci B       Date:  2014-02       Impact factor: 3.066

6.  Development of pH sensitive polyacrylamide grafted pectin hydrogel for controlled drug delivery system.

Authors:  Prashant B Sutar; Rakesh K Mishra; Kunal Pal; Ajit K Banthia
Journal:  J Mater Sci Mater Med       Date:  2007-07-10       Impact factor: 3.896

7.  The role of corneocytes in skin transport revised--a combined computational and experimental approach.

Authors:  Steffi Hansen; Arne Naegel; Michael Heisig; Gabriel Wittum; Dirk Neumann; Karl-Heinz Kostka; Peter Meiers; Claus-Michael Lehr; Ulrich F Schaefer
Journal:  Pharm Res       Date:  2009-02-25       Impact factor: 4.200

8.  Topical delivery of silymarin constituents via the skin route.

Authors:  Chi-feng Hung; Yin-ku Lin; Li-wen Zhang; Ching-hsien Chang; Jia-you Fang
Journal:  Acta Pharmacol Sin       Date:  2009-12-21       Impact factor: 7.169

9.  Influence of the flexible liposomes on the skin deposition of a hydrophilic model drug, carboxyfluorescein: dependency on their composition.

Authors:  Mohamed Badran; Khaled Shalaby; Abdullah Al-Omrani
Journal:  ScientificWorldJournal       Date:  2012-03-12

10.  Effects of various penetration enhancers on percutaneous absorption of piroxicam from emulgels.

Authors:  J Shokri; Sh Azarmi; Z Fasihi; S Hallaj-Nezhadi; A Nokhodchi; Y Javadzadeh
Journal:  Res Pharm Sci       Date:  2012-10
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