Literature DB >> 11853797

Reflux of gastric juice and glue ear in children.

Andrea Tasker, Peter W Dettmar, Marguerite Panetti, James A Koufman, John P Birchall, Jeffery P Pearson.   

Abstract

Otitis media with effusion (glue ear) is the most frequent cause of deafness in children. We investigated the role of gastric juice reflux in this disease. We measured pepsin concentrations in middle ear effusions from children using ELISA and enzyme activity assays. 45 (83%) of 54 effusions contained pepsin/pepsinogen at concentrations of up to 1000-fold greater than those in serum. Our data suggest that reflux of gastric juice could be a major cause of glue ear in children.

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Year:  2002        PMID： 11853797     DOI： 10.1016/S0140-6736(02)07665-1

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  28 in total

1.  [Gastroesophageal reflux (GER)--cause of otitis media with effusion in childhood?].

Authors:  H Sudhoff; S Euteneuer; S Dazert; A Schmidt-Choudhury; S Schreiber
Journal:  HNO       Date:  2004-01       Impact factor: 1.284

2.  Re: Autism--ear infections--glue ear--sleep disorders.

Authors:  Joseph R Herr
Journal:  J Autism Dev Disord       Date:  2003-10

3.  [Reflux and sinusitis].

Authors:  P Jecker
Journal:  HNO       Date:  2005-04       Impact factor: 1.284

4.  Pepsin like activity in bronchoalveolar lavage fluid is suggestive of gastric aspiration in lung allografts.

Authors:  C Ward; I A Forrest; I A Brownlee; G E Johnson; D M Murphy; J P Pearson; J H Dark; P A Corris
Journal:  Thorax       Date:  2005-07-29       Impact factor: 9.139

5.  Critical analysis of the laryngopharyngeal reflux literature.

Authors:  P D Karkos
Journal:  Eur Arch Otorhinolaryngol       Date:  2010-02-24       Impact factor: 2.503

6.  Cough in the community: a cross sectional survey and the relationship to gastrointestinal symptoms.

Authors:  A C Ford; D Forman; P Moayyedi; A H Morice
Journal:  Thorax       Date:  2006-06-29       Impact factor: 9.139

7.  Detection of pepsin in tracheal secretions after forced small-volume aspirations of gastric juice.

Authors:  Norma A Metheny; Thomas E Dahms; Yie-Hwa Chang; Barbara J Stewart; Patricia A Frank; Ray E Clouse
Journal:  JPEN J Parenter Enteral Nutr       Date:  2004 Mar-Apr       Impact factor: 4.016

8.  Gastroesophageal reflux disease in children with chronic otitis media with effusion.

Authors:  Fatih Yüksel; Mansur Doğan; Duran Karataş; Salim Yüce; Mehmet Şentürk; Ismail Külahli
Journal:  J Craniofac Surg       Date:  2013-03       Impact factor: 1.046

9.  Determinants of long-term outcome of patients with reflux-related ear, nose, and throat symptoms.

Authors:  Johan Poelmans; Louw Feenstra; Jan Tack
Journal:  Dig Dis Sci       Date:  2006-02       Impact factor: 3.199

Review 10.  Pathophysiological mechanisms of extraesophageal reflux in otolaryngeal disorders.

Authors:  Sören Schreiber; Désirée Garten; Holger Sudhoff
Journal:  Eur Arch Otorhinolaryngol       Date:  2008-08-13       Impact factor: 2.503
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