Literature DB >> 11853746

Phenolic compounds from Gastrodia rhizome and relaxant effects of related compounds on isolated smooth muscle preparation.

Junko Hayashi1, Toshikazu Sekine, Shigeyoshi Deguchi, Qing Lin, Syunji Horie, Shizuko Tsuchiya, Shingo Yano, Kazuo Watanabe, Fumio Ikegami.   

Abstract

Gastrol (1), together with 10 known phenolic compounds, has been isolated from the MeOH extract of the rhizomes of Gastrodia elata Blume (Orchidaceae), and their structures were elucidated by detailed spectral analyses including by 2D NMR spectroscopic analyses. The relaxant effects of these constituents on smooth muscle preparations isolated from guinea-pig ileum were also studied in order to reveal their characteristic pharmacological activities.

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Year:  2002        PMID： 11853746     DOI： 10.1016/s0031-9422(02)00008-0

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  14 in total

1.  Draft genomic sequence of Armillaria gallica 012m: insights into its symbiotic relationship with Gastrodia elata.

Authors:  Mengtao Zhan; Menghua Tian; Weiguang Wang; Ganpeng Li; Xiaokai Lu; Guolei Cai; Haiying Yang; Gang Du; Lishuxin Huang
Journal:  Braz J Microbiol       Date:  2020-06-22       Impact factor: 2.476

2.  Gastrodia elata decreases isoprenaline potency and enhances spontaneous phasic activity in the rat detrusor.

Authors:  Ivy Wen Jia Teong; Amy An Ru Ko; Minghao Li; Klaus Heese; Willmann Liang
Journal:  Int J Physiol Pathophysiol Pharmacol       Date:  2010-11-22

3.  A new drug design targeting the adenosinergic system for Huntington's disease.

Authors:  Nai-Kuei Huang; Jung-Hsin Lin; Jiun-Tsai Lin; Chia-I Lin; Eric Minwei Liu; Chun-Jung Lin; Wan-Ping Chen; Yuh-Chiang Shen; Hui-Mei Chen; Jhih-Bin Chen; Hsing-Lin Lai; Chieh-Wen Yang; Ming-Chang Chiang; Yu-Shuo Wu; Chen Chang; Jiang-Fan Chen; Jim-Min Fang; Yun-Lian Lin; Yijuang Chern
Journal:  PLoS One       Date:  2011-06-21       Impact factor: 3.240

4.  Gastrodia Elata Bl Attenuates Cocaine-Induced Conditioned Place Preference and Convulsion, but not Behavioral Sensitization in Mice: Importance of GABA(A) Receptors.

Authors:  E-J Shin; J-H Bach; T-T L Nguyen; B-D Jung; K-W Oh; M J Kim; C G Jang; S F Ali; S K Ko; C H Yang; H-C Kim
Journal:  Curr Neuropharmacol       Date:  2011-03       Impact factor: 7.363

5.  Effects of acidic polysaccharides from gastrodia rhizome on systolic blood pressure and serum lipid concentrations in spontaneously hypertensive rats fed a high-fat diet.

Authors:  Ok-Hwan Lee; Kyung-Im Kim; Chan-Kyu Han; Young-Chan Kim; Hee-Do Hong
Journal:  Int J Mol Sci       Date:  2012-01-11       Impact factor: 6.208

6.  Tianma modulates blood vessel tonicity.

Authors:  Lin Feng; Arulmani Manavalan; Manisha Mishra; Siu Kwan Sze; Jiang-Miao Hu; Klaus Heese
Journal:  Open Biochem J       Date:  2012-06-14

Review 7.  Gastrodiae Rhizoma (tiān má): a review of biological activity and antidepressant mechanisms.

Authors:  Pei-Ju Chen; Lee-Yan Sheen
Journal:  J Tradit Complement Med       Date:  2011-10

8.  Insight into Medicinal Chemistry Behind Traditional Chinese Medicines: p-Hydroxybenzyl Alcohol-Derived Dimers and Trimers from Gastrodia elata.

Authors:  Yanan Wang; Min Zhang; Xue Zhou; Chengbo Xu; Chenggen Zhu; Yuhe Yuan; Naihong Chen; Yongchun Yang; Qinglan Guo; Jiangong Shi
Journal:  Nat Prod Bioprospect       Date:  2020-08-06

9.  Simultaneous Qualitative Assessment and Quantitative Analysis of Metabolites (Phenolics, Nucleosides and Amino Acids) from the Roots of Fresh Gastrodia elata Using UPLC-ESI-Triple Quadrupole Ion MS and ESI- Linear Ion Trap High-Resolution MS.

Authors:  Sha Chen; Jun Qiu Liu; Hui Xiao; Jun Zhang; An Liu
Journal:  PLoS One       Date:  2016-03-08       Impact factor: 3.240

10.  PROTECTIVE EFFECTS OF ETHYL ACETATE EXTRACTION FROM GASTRODIA ELATA BLUME ON BLOOD-BRAIN BARRIER IN FOCAL CEREBRAL ISCHEMIA REPERFUSION.

Authors:  Fangyan He; Xiaohua Duan; Rong Dai; Wei Wang; Cui Yang; Qing Lin
Journal:  Afr J Tradit Complement Altern Med       Date:  2016-07-03
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