Literature DB >> 11853663

No DREAM, No pain. Closing the spinal gate.

Michael Costigan1, Clifford J Woolf.   

Abstract

Pain transmission in the spinal cord is regulated by a balance of facilitatory and inhibitory influences operating on the neural circuits of the somatosensory system. The transcriptional repressor DREAM acts constitutively to suppress prodynorphin expression in spinal cord neurons. Knocking out DREAM results in sufficient dynorphin expression to produce a strong reduction in generalized pain behavior, highlighting the role that intracellular molecules play in modulating pain gating in the spinal cord.

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Year:  2002        PMID： 11853663     DOI： 10.1016/s0092-8674(02)00640-2

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  20 in total

Review 1.  Spinal cord stimulation: neurophysiological and neurochemical mechanisms of action.

Authors:  Yun Guan
Journal:  Curr Pain Headache Rep       Date:  2012-06

2.  Mas-related G-protein-coupled receptors inhibit pathological pain in mice.

Authors:  Yun Guan; Qin Liu; Zongxiang Tang; Srinivasa N Raja; David J Anderson; Xinzhong Dong
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-19       Impact factor: 11.205

3.  Increases in mRNA and DREAM protein expression in the rat spinal cord after formalin induced pain.

Authors:  Idris Long; Rapeah Suppian; Zalina Ismail
Journal:  Neurochem Res       Date:  2010-12-25       Impact factor: 3.996

Review 4.  Spinal Cord Stimulation for Pain Treatment After Spinal Cord Injury.

Authors:  Qian Huang; Wanru Duan; Eellan Sivanesan; Shuguang Liu; Fei Yang; Zhiyong Chen; Neil C Ford; Xueming Chen; Yun Guan
Journal:  Neurosci Bull       Date:  2018-12-17       Impact factor: 5.203

5.  Nitric oxide modulated the expression of DREAM/calsenilin/KChIP3 in inflammatory pain of rats.

Authors:  Hong-Bo Jin; Yong-Liang Yang; Ying-Li Song; Yong-Bin Yang; Yu-Rong Li
Journal:  Inflammation       Date:  2012-12       Impact factor: 4.092

6.  Neuronal calcium-binding proteins 1/2 localize to dorsal root ganglia and excitatory spinal neurons and are regulated by nerve injury.

Authors:  Ming-Dong Zhang; Giuseppe Tortoriello; Brian Hsueh; Raju Tomer; Li Ye; Nicholas Mitsios; Lotta Borgius; Gunnar Grant; Ole Kiehn; Masahiko Watanabe; Mathias Uhlén; Jan Mulder; Karl Deisseroth; Tibor Harkany; Tomas G M Hökfelt
Journal:  Proc Natl Acad Sci U S A       Date:  2014-03-10       Impact factor: 11.205

7.  Characterization of the Photophysical, Thermodynamic, and Structural Properties of the Terbium(III)-DREAM Complex.

Authors:  Walter G Gonzalez; Victoria Ramos; Maurizio Diaz; Alyssa Garabedian; Juan Camilo Molano-Arevalo; Francisco Fernandez-Lima; Jaroslava Miksovska
Journal:  Biochemistry       Date:  2016-03-07       Impact factor: 3.162

8.  MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic pain.

Authors:  Shao-Qiu He; Zhe Li; Yu-Xia Chu; Liang Han; Qian Xu; Man Li; Fei Yang; Qin Liu; Zongxiang Tang; Yun Wang; Niyada Hin; Takashi Tsukamoto; Barbara Slusher; Vinod Tiwari; Ronen Shechter; Feng Wei; Srinivasa N Raja; Xinzhong Dong; Yun Guan
Journal:  Pain       Date:  2013-12-11       Impact factor: 6.961

Review 9.  Transcriptional regulation by cAMP and Ca2+ links the Na+/Ca2+ exchanger 3 to memory and sensory pathways.

Authors:  Nadia Gabellini
Journal:  Mol Neurobiol       Date:  2004-08       Impact factor: 5.590

10.  Increased spinal prodynorphin gene expression in reinflammation-associated hyperalgesia after neonatal inflammatory insult.

Authors:  Jack Yu-Shih Lin; Yu-Che Cheng; Julia Yi-Ru Chen; Chih-Cheng Chien; Shih-Chang Lin; Yeong-Ray Wen; Tsung-Shan Tsou; Qing-Dong Ling
Journal:  BMC Neurosci       Date:  2010-10-25       Impact factor: 3.288
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