| Literature DB >> 11852536 |
L Szabó1, H Bölcskei, B G Eszter, M Mák, C Szántay.
Abstract
The bisindole alkaloids vinblastine, vincristine, and N-formyl-leurosine were nitrated and subsequently converted to amino derivatives. In the case of compounds 5e and 5b cytotoxic activity has been found for non-small cell lung cancer and breast cancer in the concentration range tested (10(-5)-10(-9) M). 5b also showed potency in the screen for colon cancer and leukemia.Entities:
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Year: 2001 PMID： 11852536 DOI： 10.1002/1521-4184(200112)334:12<399::AID-ARDP399>3.0.CO;2-1
Source DB: PubMed Journal: Arch Pharm (Weinheim) ISSN： 0365-6233 Impact factor: 3.751