Literature DB >> 1185161

Further studies on the binding properties of cobra neurotoxin to cholinergic receptors in mouse skeletal muscle.

R Libelius, D Eaker, E Karlsson.   

Abstract

Preparations of 3H-monoacetylated derivatives of Naja naja siamensis neurotoxin siamensis 3 were found to be resistant to degradation and deacetylation during in vitro muscle incubation. A low rate of free 3H-acetate (less than 0.4%) was present in the preparations, but should not interfere with the binding of toxin to cholinergic receptors in mouse extensor digitorum longus muscles in vitro. The binding of toxin to cholinergic receptors in mouse extensor digitorum longus muscle was essentially irreversible. d-Tubocurarine antagonized the binding of toxin in both innervated and denervated muscles. Administration of actinomycin D one day after denervation prevented the appearance of new toxin binding sites in the muscles.

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Year:  1975        PMID： 1185161     DOI： 10.1007/bf01663631

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  12 in total

1.  Evidence for endocytotic uptake of cobra neurotoxin in mouse skeletal muscle.

Authors:  R Libelius
Journal:  J Neural Transm       Date:  1975       Impact factor: 3.575

2.  Binding of D-tubocurarine and alpha-bungarotoxin in normal and denervated mouse muscles.

Authors:  T H Chiu; A J Lapa; E A Barnard; E X Albuquerque
Journal:  Exp Neurol       Date:  1974-05       Impact factor: 5.330

3.  Acetylcholine receptors in muscle fibres.

Authors:  R Miledi; L T Potter
Journal:  Nature       Date:  1971-10-29       Impact factor: 49.962

4.  Modification of amino groups in Naja naja neurotoxins and the preparation of radioactive derivatives.

Authors:  E Karlsson; D Eaker; G Ponterius
Journal:  Biochim Biophys Acta       Date:  1972-02-29

5.  Types and locations of cholinergic receptor-like molecules in muscle fibres.

Authors:  C W Porter; T H Chiu; J Wieckowski; E A Barnard
Journal:  Nat New Biol       Date:  1973-01-03

6.  An electrophysiological study of the effects of D-tubocurarine, atropine, and alpha-bungarotoxin on the cholinergic receptor in innervated and chronically denervated mammalian skeletal muscles.

Authors:  A J Lapa; E X Albuquerque; J Daly
Journal:  Exp Neurol       Date:  1974-05       Impact factor: 5.330

7.  Isolation of the principal neurotoxins of two Naja naja subspecies.

Authors:  E Karlsson; H Arnberg; D Eaker
Journal:  Eur J Biochem       Date:  1971-07-15

8.  Inhibition of denervation changes in skeletal muscle by blockers of protein synthesis.

Authors:  W Grampp; J B Harris; S Thesleff
Journal:  J Physiol       Date:  1972-03       Impact factor: 5.182

9.  The binding of tetrodotoxin and alpha-bungarotoxin to normal and denervated mammalian muscle.

Authors:  D Colquhoun; H P Rang; J M Ritchie
Journal:  J Physiol       Date:  1974-07       Impact factor: 5.182

10.  Binding of -bungarotoxin to acetylcholine receptors in mammalian muscle (snake venom-denervated muscle-neonatal muscle-rat diaphragm-SDS-polyacrylamide gel electrophoresis).

Authors:  D K Berg; R B Kelly; P B Sargent; P Williamson; Z W Hall
Journal:  Proc Natl Acad Sci U S A       Date:  1972-01       Impact factor: 11.205
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  2 in total

1.  Interaction of di-iodinated 125I-labelled alpha-bungarotoxin and reversible cholinergic ligands with intact synaptic acetylcholine receptors on isolated skeletal-muscle fibres from the rat.

Authors:  P Darveniza; J A Morgan-Hughes; E J Thompson
Journal:  Biochem J       Date:  1979-09-01       Impact factor: 3.857

2.  Protamine induced intracellular uptake of horseradish peroxidase and vacuolation in mouse skeletal muscle in vitro.

Authors:  I Jirmanová; R Libelius; I Lundquist; S Thesleff
Journal:  Cell Tissue Res       Date:  1977-01-24       Impact factor: 5.249
  2 in total

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