Literature DB >> 11850433

Immunocytochemical demonstration of the equilibrative nucleoside transporter rENT1 in rat sinoatrial node.

H Musa1, H Dobrzynski, Z Berry, F Abidi, C E Cass, J D Young, S A Baldwin, M R Boyett.   

Abstract

Adenosine exerts multiple receptor-mediated effects in the heart, including a negative chronotropic effect on the sinoatrial node. The aim of this study was to investigate the distribution of the equilibrative nucleoside transporter rENT1 in rat sinoatrial node and atrial muscle. Immunocytochemistry and/or immunoblotting revealed abundant expression of this protein in plasma membranes of sinoatrial node and in atrial and ventricular cells. Because rENT1-mediated transport is likely to regulate the local concentrations of adenosine in the sinoatrial node and other parts of the heart, it represents a potential pharmacological target that might be exploited to ameliorate ischemic damage during heart surgery.

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Year:  2002        PMID： 11850433     DOI： 10.1177/002215540205000302

Source DB:  PubMed          Journal:  J Histochem Cytochem        ISSN： 0022-1554            Impact factor:   2.479


  7 in total

1.  Effects of hypoxia, glucose deprivation and recovery on the expression of nucleoside transporters and adenosine uptake in primary culture of rat cortical astrocytes.

Authors:  Zoran B Redzic; Slava A Malatiali; Maie Al-Bader; Hameed Al-Sarraf
Journal:  Neurochem Res       Date:  2010-06-25       Impact factor: 3.996

2.  Downregulation of neuronal sodium channel subunits Nav1.1 and Nav1.6 in the sinoatrial node from volume-overloaded heart failure rat.

Authors:  Yuan Du; Xin Huang; Tingzhong Wang; Ke Han; Junbo Zhang; Yutao Xi; Geru Wu; Aiqun Ma
Journal:  Pflugers Arch       Date:  2007-02-02       Impact factor: 3.657

3.  Control of glutamatergic neurotransmission in the rat spinal dorsal horn by the nucleoside transporter ENT1.

Authors:  Michael A Ackley; Ricardo J M Governo; Carol E Cass; James D Young; Stephen A Baldwin; Anne E King
Journal:  J Physiol       Date:  2003-02-28       Impact factor: 5.182

Review 4.  The equilibrative nucleoside transporter family, SLC29.

Authors:  Stephen A Baldwin; Paul R Beal; Sylvia Y M Yao; Anne E King; Carol E Cass; James D Young
Journal:  Pflugers Arch       Date:  2003-06-28       Impact factor: 3.657

5.  Requirement of neuronal- and cardiac-type sodium channels for murine sinoatrial node pacemaking.

Authors:  Ming Lei; Sandra A Jones; Jie Liu; Matthew K Lancaster; Simon S-M Fung; Halina Dobrzynski; Patrizia Camelliti; Sebastian K G Maier; Denis Noble; Mark R Boyett
Journal:  J Physiol       Date:  2004-07-14       Impact factor: 5.182

Review 6.  Xenobiotic, bile acid, and cholesterol transporters: function and regulation.

Authors:  Curtis D Klaassen; Lauren M Aleksunes
Journal:  Pharmacol Rev       Date:  2010-01-26       Impact factor: 25.468

7.  Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor.

Authors:  Riyaad Aungraheeta; Alexandra Conibear; Mark Butler; Eamonn Kelly; Sven Nylander; Andrew Mumford; Stuart J Mundell
Journal:  Blood       Date:  2016-09-30       Impact factor: 22.113
  7 in total

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