Literature DB >> 11850273

Optimal dose of amoxicillin in treatment of otitis media caused by a penicillin-resistant pneumococcus strain in the gerbil model.

Araceli Parra1, Carmen Ponte, Carlos Cenjor, Gloria García-Calvo, María José Giménez, Lorenzo Aguilar, Francisco Soriano.   

Abstract

Amoxicillin at doses of 0.2 to 5 mg/kg of body weight was administered for the treatment of pneumococcal otitis media in a gerbil model. Doses greater than or equal to 2.5 mg/kg, which resulted in concentrations in middle ear fluid of > or = 1.4 microg/ml and concentrations in serum higher than the MIC (1 microg/ml) for > or = 14% of the dosing interval, were both clinically and bacteriologically effective.

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Year:  2002        PMID： 11850273      PMCID： PMC127470          DOI： 10.1128/AAC.46.3.859-862.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Effect of clavulanic acid and/or polymorphonuclear neutrophils on amoxicillin bactericidal activity against Streptococcus pneumoniae.

Authors:  M Martín; M L Gómez-Lus; L Aguilar; P Martínez; M J Giménez; J Prieto
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1997-07       Impact factor: 3.267

2.  Resistance surveillance of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated in Asia and Europe, 1997-1998.

Authors:  D F Sahm; M E Jones; M L Hickey; D R Diakun; S V Mani; C Thornsberry
Journal:  J Antimicrob Chemother       Date:  2000-04       Impact factor: 5.790

3.  The continued emergence of drug-resistant Streptococcus pneumoniae in the United States: an update from the Centers for Disease Control and Prevention's Pneumococcal Sentinel Surveillance System.

Authors:  J C Butler; J Hofmann; M S Cetron; J A Elliott; R R Facklam; R F Breiman
Journal:  J Infect Dis       Date:  1996-11       Impact factor: 5.226

4.  Bacteriology and beta-lactamase activity in ear aspirates of acute otitis media that failed amoxicillin therapy.

Authors:  I Brook; P Yocum
Journal:  Pediatr Infect Dis J       Date:  1995-09       Impact factor: 2.129

5.  Role of Streptococcus pneumoniae and Haemophilus influenzae in the development of acute otitis media and otitis media with effusion in a gerbil model.

Authors:  F Soriano; A Parra; C Cenjor; E Nieto; G García-Calvo; M J Giménez; L Aguilar; C Ponte
Journal:  J Infect Dis       Date:  2000-02       Impact factor: 5.226

6.  Influence of recent antibiotic therapy on antimicrobial resistance of Streptococcus pneumoniae in children with acute otitis media in Spain.

Authors:  F del Castillo; F Baquero-Artigao; A Garcia-Perea
Journal:  Pediatr Infect Dis J       Date:  1998-02       Impact factor: 2.129

7.  Effect of polymorphonuclear neutrophils on serum bactericidal activity against Streptococcus pneumoniae after amoxicillin administration.

Authors:  M L Gómez-Lus; M J Giménez; J Prieto; M Martín; J Frías; L Aguilar
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1998-01       Impact factor: 3.267

8.  Pharmacology of oral antibiotics used for treatment of otitis media and tonsillopharyngitis in infants and children.

Authors:  C M Ginsburg; G H McCracken; J D Nelson
Journal:  Ann Otol Rhinol Laryngol Suppl       Date:  1981 May-Jun

Review 9.  Acute otitis media: management and surveillance in an era of pneumococcal resistance--a report from the Drug-resistant Streptococcus pneumoniae Therapeutic Working Group.

Authors:  S F Dowell; J C Butler; G S Giebink; M R Jacobs; D Jernigan; D M Musher; A Rakowsky; B Schwartz
Journal:  Pediatr Infect Dis J       Date:  1999-01       Impact factor: 2.129

10.  Penetration of amoxicillin, cefaclor, erythromycin-sulfisoxazole, and trimethoprim-sulfamethoxazole into the middle ear fluid of patients with chronic serous otitis media.

Authors:  P J Krause; N J Owens; C H Nightingale; J J Klimek; W B Lehmann; R Quintiliani
Journal:  J Infect Dis       Date:  1982-06       Impact factor: 5.226
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  3 in total

Review 1.  Animal models of Streptococcus pneumoniae disease.

Authors:  Damiana Chiavolini; Gianni Pozzi; Susanna Ricci
Journal:  Clin Microbiol Rev       Date:  2008-10       Impact factor: 26.132

2.  Antibacterial effects of amoxicillin-clavulanate against Streptococcus pneumoniae and Haemophilus influenzae strains for which MICs are high, in an in vitro pharmacokinetic model.

Authors:  Alasdair P MacGowan; Alan R Noel; Chris A Rogers; Karen E Bowker
Journal:  Antimicrob Agents Chemother       Date:  2004-07       Impact factor: 5.191

3.  Effect of antibiotic treatment delay on therapeutic outcome of experimental acute otitis media caused by Streptococcus pneumoniae strains with different susceptibilities to amoxicillin.

Authors:  Araceli Parra; Carmen Ponte; Carlos Cenjor; Carmen Martínez-Marín; Francisco Soriano
Journal:  Antimicrob Agents Chemother       Date:  2004-03       Impact factor: 5.191
  3 in total

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