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Literature DB >> 1184971

Quantitative assays of human monocyte-macrophage function.

Abstract

Monocyte-macrophages are required for the development of cell mediated immunity to a variety of microorganisms and tumors. Quantitative assays of human monocyte-macrophage function would be most useful in the evaluation of cell mediated immune function in man. Five quantitative assays are described that provide a human monocyte-macrophage function profile. These assays parallel the physiologic steps necessary for monocyte-macrophages to function as phagocytes: 1) chemotaxis, 2) opsonization, 3) phagocytosis, 4) phagocytosis-induced metabolic stimulation and 5) destruction of foreign material. Application of these quantitative assays will allow detection and dissection of disorders of monocyte-macrophage function in man.

Entities: Disease Species

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Year: 1975 PMID： 1184971 DOI： 10.1016/0022-1759(75)90114-3

Source DB: PubMed Journal: J Immunol Methods ISSN： 0022-1759 Impact factor: 2.303

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Cited

14 in total

9. Activation of human monocytes for nitroblue tetrazolium reduction and the suppression of lymphocyte response to mitogens.

Authors: M Zembala; E M Lemmel; W Uracz
Journal: Clin Exp Immunol Date: 1980-08 Impact factor: 4.330

10. Potentiation of mouse peritoneal macrophage antibacterial functions by treatment of the donor animals with the methanol extraction residue fraction of tubercle bacilli.

Authors: R Gallily; Z Douchan; D W Weiss
Journal: Infect Immun Date: 1977-11 Impact factor: 3.441

Quantitative assays of human monocyte-macrophage function.

1. Circulating immune complexes and monocyte Fc function in autoimmune diseases.

2. Chemiluminescence response of phagocytizing human monocytes.

3. Effect of soluble immune complexes of Fc and C3 receptor-dependent phagocytosis by human monocytes.

4. Monocytes in inflammatory bowel disease: phagocytosis and intracellular killing.

5. Characterization of human monocyte subpopulations by flow cytometry.

6. Binding of human factor VII and VIIa to monocytes.

7. Wheat germ agglutinin potentiates uptake of bacteria by murine peritoneal macrophages.

8. Nitroblue-tetrazolium test for the functional evaluation of phagocytic cells: a critical analysis of the methodology.

9. Activation of human monocytes for nitroblue tetrazolium reduction and the suppression of lymphocyte response to mitogens.

10. Potentiation of mouse peritoneal macrophage antibacterial functions by treatment of the donor animals with the methanol extraction residue fraction of tubercle bacilli.