BACKGROUND: The aim of this study was to develop and characterize a mouse xenograft model for the hypercalcemic-type of small cell carcinoma of the ovary (HTSCCO). PATIENTS AND METHODS: Tumor fragments were removed from a patient and cultured in six subsequent generations of nude mice. Histology, comparative genomic hybridization (CGH), electron microscopy and serum calcium levels were investigated. RESULTS: Morphology remained the same from the primary tumor of the patient through the 6th passage in the mouse. Serum calcium levels were significantly higher in the tumor-bearing mice compared to controls. CGH of the HTSCCO did not show evidence of a close relationship to either a germ cell tumor or an epithelial ovarian cancer. CONCLUSION: Some evidence was provided that the HTSCCO is an inhomogeneous tumor that is neither related to a germ cell tumor nor to an epithelial ovarian cancer, but is a distinct tumor entity.
BACKGROUND: The aim of this study was to develop and characterize a mouse xenograft model for the hypercalcemic-type of small cell carcinoma of the ovary (HTSCCO). PATIENTS AND METHODS: Tumor fragments were removed from a patient and cultured in six subsequent generations of nude mice. Histology, comparative genomic hybridization (CGH), electron microscopy and serum calcium levels were investigated. RESULTS: Morphology remained the same from the primary tumor of the patient through the 6th passage in the mouse. Serum calcium levels were significantly higher in the tumor-bearing mice compared to controls. CGH of the HTSCCO did not show evidence of a close relationship to either a germ cell tumor or an epithelial ovarian cancer. CONCLUSION: Some evidence was provided that the HTSCCO is an inhomogeneous tumor that is neither related to a germ cell tumor nor to an epithelial ovarian cancer, but is a distinct tumor entity.
Authors: Lisa F Gamwell; Karen Gambaro; Maria Merziotis; Colleen Crane; Suzanna L Arcand; Valerie Bourada; Christopher Davis; Jeremy A Squire; David G Huntsman; Patricia N Tonin; Barbara C Vanderhyden Journal: Orphanet J Rare Dis Date: 2013-02-21 Impact factor: 4.123
Authors: Anna Otte; Finn Rauprich; Juliane von der Ohe; Yuanyuan Yang; Friedrich Kommoss; Friedrich Feuerhake; Peter Hillemanns; Ralf Hass Journal: Oncotarget Date: 2015-10-13
Authors: Anna Otte; Finn Rauprich; Peter Hillemanns; Tjoung-Won Park-Simon; Juliane von der Ohe; Ralf Hass Journal: Orphanet J Rare Dis Date: 2014-08-08 Impact factor: 4.123