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Literature DB >> 1184761

Measurement of plasma renin activity by semi-micro radioimmunoassay of generated angiotensin I.

Abstract

A semi-micro method for determination of plasma renin activity (PRA) by radioimmunoassay of generated angiotensin I (AI) is described. The method permits measurement of PRA on 250 mul of plasma without loss of specificity, sensitivity, accuracy or preision. The small sample size has considerable application in terms of investigation of infants and young children. A reference range was established for healthy children on free diets. There was a 15-fold decline in PRA with age from a mean value of 1404pgAI/ml h-1 (ngAI/1. h-1) in infancy to a mean of 85 pgAI/ml h-1 (ngAI/1. h-1) in adult life.

Entities: Gene Species

Mesh：

Substances：
Angiotensin II
Renin

Year: 1975 PMID： 1184761 PMCID： PMC475790 DOI： 10.1136/jcp.28.8.625

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

17 in total

1. The renin system: Variations in man measured by radioimmunoassay or bioassay.

Authors: J E Sealey; J Gerten-Banes; J H Laragh
Journal: Kidney Int Date: 1972-04 Impact factor: 10.612

2. Plasma renin concentration: comparison of angiotensinase inhibitors and correlation with plasma renin activity and aldosterone.

Authors: M E Kodish; F H Katz
Journal: J Lab Clin Med Date: 1974-05

3. Assay of plasma renin activity using commercially available reagents.

Authors: G W Viol; P M Keane; J F Speed; E K Smith
Journal: Clin Biochem Date: 1972-12 Impact factor: 3.281

4. Measurement of plasma renin activity by angiotensin I radioimmunoassay: (I) an assessment of some methodological aspects.

Authors: R Malvano; G C Zucchelli; U Rosa; A Salvetti
Journal: J Nucl Biol Med Date: 1972 Jan-Mar

5. [Determination of plasma renin activity using the radioimmunoassay for angiotensin I].

Authors: W Brech; H E Franz
Journal: Klin Wochenschr Date: 1972-03-15

6. Radioimmunoassay of angiotensin I: comparison of two renin activity methods and use for other measurements of the renin system.

Authors: F H Katz; J A Smith
Journal: Clin Chem Date: 1972-06 Impact factor: 8.327

10. Tailored Assays for Pharmacokinetic and Pharmacodynamic Investigations of Aliskiren and Enalapril in Children: An Application in Serum, Urine, and Saliva.

Authors: Bjoern B Burckhardt; Jutta Tins; Sergej Ramusovic; Stephanie Läer
Journal: J Pediatr Pharmacol Ther Date: 2015 Nov-Dec

Measurement of plasma renin activity by semi-micro radioimmunoassay of generated angiotensin I.

1. The renin system: Variations in man measured by radioimmunoassay or bioassay.

2. Plasma renin concentration: comparison of angiotensinase inhibitors and correlation with plasma renin activity and aldosterone.

3. Assay of plasma renin activity using commercially available reagents.

4. Measurement of plasma renin activity by angiotensin I radioimmunoassay: (I) an assessment of some methodological aspects.

5. [Determination of plasma renin activity using the radioimmunoassay for angiotensin I].

6. Radioimmunoassay of angiotensin I: comparison of two renin activity methods and use for other measurements of the renin system.

7. Proceedings: Plasma renin activity and aldosterone concentration in children.

8. Measurement of renin activity, concentration and substrate in rat plasma by radioimmunoassay of angiotensin I.

9. Measurement of renin activity in plasma by a radioimmunoassay for angiotensin I.

10. Radioimmunoassay determination of plasma-renin activity.

1. The captopril test: an aid to investigation of hypertension.

2. Congenital adrenal hyperplasia: renin and steroid values during treatment.

3. Salt-losing syndrome in 2 infants with defective 18-dehydrogenation in aldosterone biosynthesis.

4. Tubular proteinuria in reflux nephropathy: post ureteric re-implantation.

5. Renal tubular dysfunction in methylmalonic acidaemia.

6. Plasma renin activity and aldosterone concentration in the human newborn.

7. Prediction of blood pressure from plasma renin activity in reflux nephropathy.

8. Pseudohypoaldosteronism.

9. Renin and aldosterone response in human newborns to acute change in blood volume.

10. Tailored Assays for Pharmacokinetic and Pharmacodynamic Investigations of Aliskiren and Enalapril in Children: An Application in Serum, Urine, and Saliva.