Literature DB >> 11846837

Inhibition of tumour invasion and angiogenesis by epigallocatechin gallate (EGCG), a major component of green tea.

Y D Jung1, L M Ellis.   

Abstract

Epidemiological studies have suggested that consumption of green tea may decrease cancer risk. In addition, abundant pre-clinical data from several laboratories have provided convincing evidence that polyphenols present in green tea afford protection against cancer in both in vivo and in vitro studies. Recently, epigallocatechin gallate (EGCG), a putative chemopreventive agent and a major component of green tea, was reported to inhibit tumour invasion and angiogenesis, processes that are essential for tumour growth and metastasis. Understanding the basic principles by which EGCG inhibits tumour invasion and angiogenesis may lead to the development of new therapeutic strategies, in addition to supporting the role of green tea as a cancer chemopreventive agent.

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Year:  2001        PMID： 11846837      PMCID： PMC2517785          DOI： 10.1046/j.1365-2613.2001.00205.x

Source DB:  PubMed          Journal:  Int J Exp Pathol        ISSN： 0959-9673            Impact factor:   1.925


  54 in total

1.  Angiogenesis inhibited by drinking tea.

Authors:  Y Cao; R Cao
Journal:  Nature       Date:  1999-04-01       Impact factor: 49.962

Review 2.  Green tea in chemoprevention of cancer.

Authors:  H Mukhtar; N Ahmad
Journal:  Toxicol Sci       Date:  1999-12       Impact factor: 4.849

3.  Synergistic effects of (--)-epigallocatechin gallate with (--)-epicatechin, sulindac, or tamoxifen on cancer-preventive activity in the human lung cancer cell line PC-9.

Authors:  M Suganuma; S Okabe; Y Kai; N Sueoka; E Sueoka; H Fujiki
Journal:  Cancer Res       Date:  1999-01-01       Impact factor: 12.701

4.  Enhanced inhibition of experimental metastasis by the combination chemotherapy of Cu-Zn SOD and adriamycin.

Authors:  K Kogawa; H Muramatsu; M Tanaka; Y Nishihori; S Hagiwara; K Kuribayashi; K Nakamura; K Koike; S Sakamaki; Y Niitsu
Journal:  Clin Exp Metastasis       Date:  1999-05       Impact factor: 5.150

Review 5.  Prostate cancer chemoprevention by green tea.

Authors:  S Gupta; N Ahmad; H Mukhtar
Journal:  Semin Urol Oncol       Date:  1999-05

6.  Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis.

Authors:  R M Shaheen; D W Davis; W Liu; B K Zebrowski; M R Wilson; C D Bucana; D J McConkey; G McMahon; L M Ellis
Journal:  Cancer Res       Date:  1999-11-01       Impact factor: 12.701

7.  Urokinase plasminogen activator/urokinase-specific surface receptor expression and matrix invasion by breast cancer cells requires constitutive p38alpha mitogen-activated protein kinase activity.

Authors:  S Huang; L New; Z Pan; J Han; G R Nemerow
Journal:  J Biol Chem       Date:  2000-04-21       Impact factor: 5.157

8.  Inhibitory effects of carotenoids on the invasion of rat ascites hepatoma cells in culture.

Authors:  Y Kozuki; Y Miura; K Yagasaki
Journal:  Cancer Lett       Date:  2000-04-03       Impact factor: 8.679

9.  Extracellular signal-regulated kinase activation is required for up-regulation of vascular endothelial growth factor by serum starvation in human colon carcinoma cells.

Authors:  Y D Jung; K Nakano; W Liu; G E Gallick; L M Ellis
Journal:  Cancer Res       Date:  1999-10-01       Impact factor: 12.701

Review 10.  Green tea and cancer in humans: a review of the literature.

Authors:  J L Bushman
Journal:  Nutr Cancer       Date:  1998       Impact factor: 2.900
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  36 in total

1.  EGCG ameliorates the suppression of long-term potentiation induced by ischemia at the Schaffer collateral-CA1 synapse in the rat.

Authors:  Jie Ding; Gang Fu; Yan Zhao; Zhenyong Cheng; Yang Chen; Bo Zhao; Wei He; Lian-Jun Guo
Journal:  Cell Mol Neurobiol       Date:  2011-11-11       Impact factor: 5.046

2.  Disrupting antibiotic resistance propagation by inhibiting the conjugative DNA relaxase.

Authors:  Scott A Lujan; Laura M Guogas; Heather Ragonese; Steven W Matson; Matthew R Redinbo
Journal:  Proc Natl Acad Sci U S A       Date:  2007-07-13       Impact factor: 11.205

3.  Activity of green tea polyphenol epigallocatechin-3-gallate against ovarian carcinoma cell lines.

Authors:  Yong Wook Kim; Su Mi Bae; Joon Mo Lee; Sung Eun Namkoong; Sei Jun Han; Byoung Rai Lee; Insu P Lee; Sang Hee Kim; Young Joo Lee; Chong Kook Kim; Yong-Wan Kim; Woong Shick Ahn
Journal:  Cancer Res Treat       Date:  2004-10-31       Impact factor: 4.679

Review 4.  Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds.

Authors:  A R M Ruhul Amin; Phillip A Karpowicz; Thomas E Carey; Jack Arbiser; Rita Nahta; Zhuo G Chen; Jin-Tang Dong; Omer Kucuk; Gazala N Khan; Gloria S Huang; Shijun Mi; Ho-Young Lee; Joerg Reichrath; Kanya Honoki; Alexandros G Georgakilas; Amedeo Amedei; Amr Amin; Bill Helferich; Chandra S Boosani; Maria Rosa Ciriolo; Sophie Chen; Sulma I Mohammed; Asfar S Azmi; W Nicol Keith; Dipita Bhakta; Dorota Halicka; Elena Niccolai; Hiromasa Fujii; Katia Aquilano; S Salman Ashraf; Somaira Nowsheen; Xujuan Yang; Alan Bilsland; Dong M Shin
Journal:  Semin Cancer Biol       Date:  2015-03-06       Impact factor: 15.707

5.  Comparison of (-)-epigallocatechin-3-gallate elicited liver and small intestine gene expression profiles between C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice.

Authors:  Guoxiang Shen; Changjiang Xu; Rong Hu; Mohit R Jain; Sujit Nair; Wen Lin; Chung S Yang; Jefferson Y Chan; A-N Tony Kong
Journal:  Pharm Res       Date:  2005-08-16       Impact factor: 4.200

6.  (-)-Epigallocatechin-3-gallate inhibits nasopharyngeal cancer stem cell self-renewal and migration and reverses the epithelial-mesenchymal transition via NF-κB p65 inactivation.

Authors:  Ya-Jun Li; Shun-Long Wu; Song-Mei Lu; Fang Chen; Ying Guo; Sheng-Min Gan; Yan-Long Shi; Shuang Liu; Shao-Lin Li
Journal:  Tumour Biol       Date:  2014-12-07

7.  Inhibition of invasion and up-regulation of E-cadherin expression in human malignant melanoma cell line A375 by (-)-epigallocatechin-3-gallate.

Authors:  Yan Wu; Yun Lin; Houjun Liu; Jiawen Li
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2008-06-19

8.  Effects of long-term tea polyphenols consumption on hepatic microsomal drug-metabolizing enzymes and liver function in Wistar rats.

Authors:  Tao-Tao Liu; Ning-Sheng Liang; Yan Li; Fan Yang; Yi Lu; Zi-Qing Meng; Li-Sheng Zhang
Journal:  World J Gastroenterol       Date:  2003-12       Impact factor: 5.742

9.  (-)-Epigallocatechin-3-gallate inhibits growth of gastric cancer by reducing VEGF production and angiogenesis.

Authors:  Bao-He Zhu; Wen-Hua Zhan; Zheng-Rong Li; Zhao Wang; Yu-Long He; Jun-Sheng Peng; Shi-Rong Cai; Jin-Ping Ma; Chang-Hua Zhang
Journal:  World J Gastroenterol       Date:  2007-02-28       Impact factor: 5.742

10.  Binding of natural and synthetic polyphenols to human dihydrofolate reductase.

Authors:  Luís Sánchez-Del-Campo; Magalí Sáez-Ayala; Soledad Chazarra; Juan Cabezas-Herrera; José Neptuno Rodríguez-López
Journal:  Int J Mol Sci       Date:  2009-12-18       Impact factor: 6.208
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