Literature DB >> 11844707

New indene-derivatives with anti-proliferative properties.

Ioanna-Maria Karaguni1, Karl-Heinz Glüsenkamp, Anette Langerak, Christoph Geisen, Volker Ullrich, Günther Winde, Tarik Möröy, Oliver Müller.   

Abstract

Metabolites of the non-steroidal anti-inflammatory drug Sulindac inhibit cell proliferation by affecting several intracellular signaling pathways including the tumorigenic Ras/Raf/MAPK pathway. Here, we report the synthesis of eight new indene derivatives derived from the Sulindac structure, and present data on their anti-proliferative properties and their effects on the p21ras protein.

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Year:  2002        PMID： 11844707     DOI： 10.1016/s0960-894x(01)00839-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

Review 1.  Drugging the undruggable RAS: Mission possible?

Authors:  Adrienne D Cox; Stephen W Fesik; Alec C Kimmelman; Ji Luo; Channing J Der
Journal:  Nat Rev Drug Discov       Date:  2014-10-17       Impact factor: 84.694

Review 2.  The RAS-Effector Interaction as a Drug Target.

Authors:  Adam B Keeton; E Alan Salter; Gary A Piazza
Journal:  Cancer Res       Date:  2017-01-06       Impact factor: 12.701

3.  Stereoselective Synthesis of Trisubstituted Vinyl Bromides by Addition of Alkynes to Oxocarbenium Ions.

Authors:  Andrew R Ehle; Melissa G Morris; Bryan D Klebon; Glenn P A Yap; Mary P Watson
Journal:  Synlett       Date:  2015-09-14       Impact factor: 2.454

4.  [3,3]-Sigmatropic rearrangement/5-exo-dig cyclization reactions of benzyl alkynyl ethers: synthesis of substituted 2-indanones and indenes.

Authors:  Armen A Tudjarian; Thomas G Minehan
Journal:  J Org Chem       Date:  2011-03-25       Impact factor: 4.354

5.  Tuning isoform selectivity and bortezomib sensitivity with a new class of alkenyl indene PDI inhibitor.

Authors:  Reeder M Robinson; Leticia Reyes; Ravyn M Duncan; Haiyan Bian; Eric D Strobel; Sarah L Hyman; Allen B Reitz; Nathan G Dolloff
Journal:  Eur J Med Chem       Date:  2019-11-21       Impact factor: 6.514

Review 6.  Pharmacological targeting of RAS: Recent success with direct inhibitors.

Authors:  John P O'Bryan
Journal:  Pharmacol Res       Date:  2018-10-23       Impact factor: 7.658

7.  Synthetic approaches to multifunctional indenes.

Authors:  Neus Mesquida; Sara López-Pérez; Immaculada Dinarès; Ermitas Alcalde
Journal:  Beilstein J Org Chem       Date:  2011-12-29       Impact factor: 2.883

8.  A potent lead induces apoptosis in pancreatic cancer cells.

Authors:  Zuojia Liu; Dan Li; Wenjing Zhao; Xiliang Zheng; Jin Wang; Erkang Wang
Journal:  PLoS One       Date:  2012-06-20       Impact factor: 3.240

9.  Enantioselective Synthesis of Spiroindenes by Enol-Directed Rhodium(III)-Catalyzed C-H Functionalization and Spiroannulation.

Authors:  Suresh Reddy Chidipudi; David J Burns; Imtiaz Khan; Hon Wai Lam
Journal:  Angew Chem Int Ed Engl       Date:  2015-09-25       Impact factor: 15.336

10.  An engineered protein antagonist of K-Ras/B-Raf interaction.

Authors:  Monique J Kauke; Michael W Traxlmayr; Jillian A Parker; Jonathan D Kiefer; Ryan Knihtila; John McGee; Greg Verdine; Carla Mattos; K Dane Wittrup
Journal:  Sci Rep       Date:  2017-07-19       Impact factor: 4.379
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