| Literature DB >> 11844687 |
Satoshi Sunami1, Mitsuru Ohkubo, Takeshi Sagara, Jun Ono, Shuichi Asahi, Seita Koito, Hajime Morishima.
Abstract
Replacement of the thiol groups in 1, a potent and highly selective Candida albicans GGTase I inhibitor discovered through screening, with an imidazole ring was achieved by using solid phase synthesis. A non-thiol compound, 7, was found as a representative of a new class of potent C. albicans GGTase I inhibitor with high selectivity against human GGTase I.Entities:
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Year: 2002 PMID： 11844687 DOI： 10.1016/s0960-894x(01)00813-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823