Literature DB >> 11844672

Total synthesis and semi-synthetic approaches to analogues of antibacterial natural product althiomycin.

Paola Zarantonello1, Colin P Leslie, Rafael Ferritto, Wieslaw M Kazmierski.   

Abstract

Numerous analogues of the naturally occurring antibiotic althiomycin have been synthesised exploiting both total- and semi-synthetic methodologies. The antibacterial activity of these derivatives has been determined in whole cell assays and indicates the natural product exhibits a restricted SAR.

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Year:  2002        PMID： 11844672     DOI： 10.1016/s0960-894x(01)00802-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

Review 1.  Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis.

Authors:  Abraham J Waldman; Tai L Ng; Peng Wang; Emily P Balskus
Journal:  Chem Rev       Date:  2017-04-04       Impact factor: 60.622

2.  Exploring the Diversity and Antibacterial Potentiality of Cultivable Actinobacteria from the Soil of the Saxaul Forest in Southern Gobi Desert in Mongolia.

Authors:  Shao-Wei Liu; Norovsuren Jadambaa; Arina A Nikandrova; Ilya A Osterman; Cheng-Hang Sun
Journal:  Microorganisms       Date:  2022-05-09

3.  Total synthesis of the marine cyanobacterial cyclodepsipeptide apratoxin A.

Authors:  Jiehao Chen; Craig J Forsyth
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-01       Impact factor: 11.205

4.  Efficient microwave assisted synthesis of optically active bicyclic 2-pyridinones via delta2-thiazolines.

Authors:  Hans Emtenäs; Camilla Taflin; Fredrik Almqvist
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

5.  The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin.

Authors:  Amy J Gerc; Lijiang Song; Gregory L Challis; Nicola R Stanley-Wall; Sarah J Coulthurst
Journal:  PLoS One       Date:  2012-09-18       Impact factor: 3.240
  5 in total

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