BACKGROUND: QT dispersion (QTd) has been found to correlate to the amount of viable myocardium in patients with Q-wave myocardial infarction and well-preserved LV function. However, this relationship is unknown in patients with severe left ventricular dysfunction. METHODS: Thirty-four patients with prior large myocardial infarction and severe left ventricular dysfunction underwent Tc-99m sestamibi single photon emission cardiac tomography (SPECT) and F-18 fluorodeoxyglucose (FDG) SPECT. Viability was defined as a defect relative count density (DCD) of at least 20% greater on FDG SPECT. QTd, corrected QT dispersion (QTcd), and QT coefficient of variation (cv) in patients with viable myocardium was compared to those without viable myocardium in the infarct area. RESULTS: Thirteen patients were excluded from analysis for poor FDG images or inadequate ECG tracings. Of the remaining patients, 10 (48%) were found to have viability on FDG SPECT. QTd, QTcd, and QTcv in patients with viability were: 58 +/- 22 ms, 61 +/- 23 ms, and 4.81 +/- 1.76%, respectively, which did not differ significantly from those in patients without viability (QTd = 56 +/- 14 ms, QTcd = 70 +/- 16 ms and Qtcv = 5.06 +/- 1.20% [P = NS]). Moreover, neither FDG defect size, nor LVEF correlated with QTd. CONCLUSIONS: This study indicates no relationship between QTd and viability in patients with myocardial infarction and severe left ventricular dysfunction.
BACKGROUND: QT dispersion (QTd) has been found to correlate to the amount of viable myocardium in patients with Q-wave myocardial infarction and well-preserved LV function. However, this relationship is unknown in patients with severe left ventricular dysfunction. METHODS: Thirty-four patients with prior large myocardial infarction and severe left ventricular dysfunction underwent Tc-99m sestamibi single photon emission cardiac tomography (SPECT) and F-18fluorodeoxyglucose (FDG) SPECT. Viability was defined as a defect relative count density (DCD) of at least 20% greater on FDG SPECT. QTd, corrected QT dispersion (QTcd), and QT coefficient of variation (cv) in patients with viable myocardium was compared to those without viable myocardium in the infarct area. RESULTS: Thirteen patients were excluded from analysis for poor FDG images or inadequate ECG tracings. Of the remaining patients, 10 (48%) were found to have viability on FDG SPECT. QTd, QTcd, and QTcv in patients with viability were: 58 +/- 22 ms, 61 +/- 23 ms, and 4.81 +/- 1.76%, respectively, which did not differ significantly from those in patients without viability (QTd = 56 +/- 14 ms, QTcd = 70 +/- 16 ms and Qtcv = 5.06 +/- 1.20% [P = NS]). Moreover, neither FDG defect size, nor LVEF correlated with QTd. CONCLUSIONS: This study indicates no relationship between QTd and viability in patients with myocardial infarction and severe left ventricular dysfunction.
Authors: M Arnese; J H Cornel; A Salustri; A Maat; A Elhendy; A E Reijs; F J Ten Cate; D Keane; A H Balk; J R Roelandt Journal: Circulation Date: 1995-06-01 Impact factor: 29.690
Authors: W H Martin; D Delbeke; J A Patton; B Hendrix; Z Weinfeld; I Ohana; R M Kessler; M P Sandler Journal: J Nucl Med Date: 1995-06 Impact factor: 10.057
Authors: J J Bax; F C Visser; P K Blanksma; M A Veening; E S Tan; T M Willemsen; A van Lingen; G J Teule; W Vaalburg; K I Lie; C A Visser Journal: J Nucl Med Date: 1996-10 Impact factor: 10.057
Authors: F Bogun; K K Chan; M Harvey; R Goyal; M Castellani; M Niebauer; E Daoud; K C Man; S A Strickberger; F Morady Journal: Am J Cardiol Date: 1996-02-01 Impact factor: 2.778
Authors: Ivan Stankovic; Srdjan Kafedzic; Aleksandra Janicijevic; Radosava Cvjetan; Tijana Vulovic; Milica Jankovic; Ivan Ilic; Biljana Putnikovic; Aleksandar N Neskovic Journal: Int J Cardiovasc Imaging Date: 2017-05-27 Impact factor: 2.357