Paulino E Goco1, Fred J Stucker. 1. Otolaryngology-Head and Neck Surgery Service, Madigan Army Medical Center, Tacoma, WA 98431, USA. Paulino.Goco@NW.AMEDD.ARMY.MIL
Abstract
BACKGROUND: Conventional carbon dioxide (CO(2)) skin laser resurfacing reverses the effects of photoaging. A recent clinical series reported the efficacy of performing subdermal CO(2)resurfacing to obtain the same skin contracture as epidermal skin resurfacing. OBJECTIVE: To assess surface area contraction that occurs with subdermal CO(2) laser resurfacing in the rat model. DESIGN: A nonrandomized control study was performed using 32 rats. The 3 test groups were divided by CO(2) laser strength (5 vs 7 W) and the pattern of resurfacing (cross-hatched vs parallel lines). MATERIALS AND METHODS: The rats underwent subdermal continuous 2-mm defocused CO(2)beam treatment of the right-sided experimental flap. The left subdermal flap acted as a control. In the first group (n = 12), a subdermal cross-hatching of the subdermal flap was performed with 7 W. The second group (n = 10) was resurfaced in a parallel fashion with 7 W. The third group (n = 10) was resurfaced in a parallel fashion with 5 W. Measurements of skin area were taken immediately after laser resurfacing and 3 weeks after the treatment. RESULTS: None of the treatment arms showed a change in skin surface area immediately or 3 weeks after treatment. In the first treatment group, all of the treated flaps showed an entire full-thickness slough. Of the controls, 75% showed minimal sloughing. The second and third experimental groups showed a 100% slough of the flaps. Of the 20 control flaps in the second and third groups, only 1 had a partial slough. CONCLUSIONS: In this animal model, subdermal CO(2) laser resurfacing showed a 100% rate of skin sloughing. No change in skin surface area was evident immediately or 3 weeks after treatment.
BACKGROUND: Conventional carbon dioxide (CO(2)) skin laser resurfacing reverses the effects of photoaging. A recent clinical series reported the efficacy of performing subdermal CO(2)resurfacing to obtain the same skin contracture as epidermal skin resurfacing. OBJECTIVE: To assess surface area contraction that occurs with subdermal CO(2) laser resurfacing in the rat model. DESIGN: A nonrandomized control study was performed using 32 rats. The 3 test groups were divided by CO(2) laser strength (5 vs 7 W) and the pattern of resurfacing (cross-hatched vs parallel lines). MATERIALS AND METHODS: The rats underwent subdermal continuous 2-mm defocused CO(2)beam treatment of the right-sided experimental flap. The left subdermal flap acted as a control. In the first group (n = 12), a subdermal cross-hatching of the subdermal flap was performed with 7 W. The second group (n = 10) was resurfaced in a parallel fashion with 7 W. The third group (n = 10) was resurfaced in a parallel fashion with 5 W. Measurements of skin area were taken immediately after laser resurfacing and 3 weeks after the treatment. RESULTS: None of the treatment arms showed a change in skin surface area immediately or 3 weeks after treatment. In the first treatment group, all of the treated flaps showed an entire full-thickness slough. Of the controls, 75% showed minimal sloughing. The second and third experimental groups showed a 100% slough of the flaps. Of the 20 control flaps in the second and third groups, only 1 had a partial slough. CONCLUSIONS: In this animal model, subdermal CO(2) laser resurfacing showed a 100% rate of skin sloughing. No change in skin surface area was evident immediately or 3 weeks after treatment.