Literature DB >> 11843616

Alkynenitriles: chelation-controlled conjugate additions.

Fraser F Fleming1, Venugopal Gudipati, Omar W Steward.   

Abstract

[reaction: see text] Chelation between gamma-hydroxybutynenitrile and Grignard reagents triggers a particularly facile anionic conjugate addition reaction. Structurally diverse Grignard reagents add with equal efficiency, providing an intermediate anion that stereoselectively alkylates benzaldehyde in an overall addition-alkylation reaction.

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Year:  2002        PMID： 11843616     DOI： 10.1021/ol017286c

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Preparation of Disubstituted Phenyl Propargyl Alcohols, their Use in Oxathiolene Oxide Synthesis, and Evaluation of the Oxathiolene Oxide Products as Anticarcinogenic Enzyme Inducers.

Authors:  Maben Ying; Matthew G Smentek; Rong Ma; Cynthia S Day; Suzy V Torti; Mark E Welker
Journal:  Lett Org Chem       Date:  2009-04-01       Impact factor: 0.867

2.  G3 assisted rational design of chemical sensor array using carbonitrile neutral receptors.

Authors:  Ahmad Nazmi Rosli; Maizathul Akmam Abu Bakar; Ninie Suhana Abdul Manan; Pei Meng Woi; Vannajan Sanghiran Lee; Sharifuddin Md Zain; Mohd Rais Ahmad; Yatimah Alias
Journal:  Sensors (Basel)       Date:  2013-10-14       Impact factor: 3.576
  2 in total

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